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Positions In The Glun2c-Containing Nmdar Regulate Alcohol Sensitivity And Ion Channel Gating, Man Wu
Positions In The Glun2c-Containing Nmdar Regulate Alcohol Sensitivity And Ion Channel Gating, Man Wu
Master's Theses (2009 -)
The N-methyl-D-aspartate (NMDA) receptor, a subtype of glutamate-gated ion channel, has been shown to be a major target of ethanol in the central nervous system (CNS). Previous studies have identified positions in the third and fourth membrane-associated (M) domains of the NMDAR GluN1 and GluN2A subunits that influence ethanol sensitivity. Among the alcohol sensitive sites, a methionine residue is highly conserved in all GluN1 and GluN2 subunits. We proposed the methionine position (Met-821) in the M4 domain of the GluN2C subunit can regulate ethanol sensitivity and ion channel gating. 14 mutations were made at the methionine position, 7 substitutions yielded …