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Full-Text Articles in Biology
A Coupled Experimental And Computational Approach To Quantify Deleterious Hemodynamics, Vascular Alterations, And Mechanisms Of Long-Term Morbidity In Response To Aortic Coarctati, Arjun Menon, David C. Wendell, Hongfeng Wang, Thomas J. Eddinger, Jeffrey M. Toth, Ronak Jashwant Dholakia, Paul M. Larsen, Eric S. Jensen, John F. Ladisa
A Coupled Experimental And Computational Approach To Quantify Deleterious Hemodynamics, Vascular Alterations, And Mechanisms Of Long-Term Morbidity In Response To Aortic Coarctati, Arjun Menon, David C. Wendell, Hongfeng Wang, Thomas J. Eddinger, Jeffrey M. Toth, Ronak Jashwant Dholakia, Paul M. Larsen, Eric S. Jensen, John F. Ladisa
Biomedical Engineering Faculty Research and Publications
Introduction
Coarctation of the aorta (CoA) is associated with morbidity despite treatment. Although mechanisms remain elusive, abnormal hemodynamics and vascular biomechanics are implicated. We present a novel approach that facilitates quantification of coarctation-induced mechanical alterations and their impact on vascular structure and function, without genetic or confounding factors.
Methods
Rabbits underwent thoracic CoA at 10 weeks of age (~ 9 human years) to induce a 20 mm Hg blood pressure (BP) gradient using permanent or dissolvable suture thereby replicating untreated and corrected CoA. Computational fluid dynamics (CFD) was performed using imaging and BP data at 32 weeks to quantify velocity, …