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Daxx As A Restrictor Of Tumor Initiating Cell Survival In Er+ Breast Cancer And Its Therapeutic Implications, Daniel Seamus Peiffer
Daxx As A Restrictor Of Tumor Initiating Cell Survival In Er+ Breast Cancer And Its Therapeutic Implications, Daniel Seamus Peiffer
Dissertations
Breast cancer overall is the second most common cause of cancer related death in women, with one in eight women being diagnosed during their lifetime. Breast cancer itself is divided into subtypes based on the expression levels of the hormone receptors including the estrogen receptor (ER) and the progesterone receptor (PR), as well as expression of the growth factor receptor epidermal growth factor receptor 2 (HER2). ER+ breast cancer is the most common breast cancer diagnosis, and these tumors are defined as being initially dependent on activation of the receptor for growth. Based on this, targeted endocrine therapies (ETs) have …