Biology Commons^™

Pathogenesis And Therapeutic Considerations For Nonalcoholic Fatty Liver Disease, Elijah Chung

Senior Honors Theses

A product of the Westernized, high-fat diet, non-alcoholic fatty liver disease (NAFLD) has emerged as the leading cause of chronic liver disease, affecting one-fourth of the world's population. NAFLD is a progressive disease arising from a multisystem response to excess lipids in the blood, adipose tissue, and liver. Despite the prevalence of NAFLD and its well-studied bidirectional association with obesity and type 2 diabetes mellitus and obesity, there is a shocking scarcity of available treatments aside from diet and lifestyle changes. Thus, further research on NAFLD and potential therapies is urgently needed. This paper will illustrate the major pathways associated …

How Dna Reveals God’S Design, Alan L. Gillen

Faculty Publications and Presentations

Codes are big in today’s world: QR codes, barcodes, computer codes, cell phone codes, and more. Specific information is needed to identify, diagnose, and inform. DNA is the code for life: microbes, plants, parasites, animals, and man. DNA Day is April 25 because it was this day in history (April 25, 1953) when James Watson and Francis Crick described DNA as the double helix and the code for life. Although we consider DNA the genetic blueprint for life, it has only been known for 80 years. On February 1, 1944, Oswald Avery, Colin MacLeod, and Maclyn McCarty wrote a revolutionary …

Exploring Racial And Ethnic Disparities In Alzheimer's Disease And Related Dementias: Prevalence, Healthcare Utilization, And Costs, Michael E. Myers Ii

Doctoral Dissertations and Projects

Objective: This study aims to investigate the disparities in prevalence rates, healthcare utilization patterns, and healthcare costs associated with Alzheimer’s Disease and Related Dementias (ADRD) among various racial and ethnic groups over time. Methods: Utilizing data from the medical expenditure panel survey over a five-year period, this study employs factorial logistic regression to analyze ADRD prevalence rates and multivariate analysis of variance to examine healthcare utilization and costs. The analysis focuses on weighted populations to account for the representation of racial and ethnic groups, ensuring the generalizability of the findings. Results: The study identifies statistically significant disparities in ADRD prevalence, …

Celebrating Leeuwenhoek’S Life 300 Years Later, Alan L. Gillen

Faculty Publications and Presentations

Antony van Leeuwenhoek entered eternity 300 years ago (August 26, 1723). He made hundreds of discoveries with his simple microscope. Perhaps his most notable discovery was of bacteria and its many shapes. He found great joy in God [http://answersingenesis.org/god/] ’s smallest creatures. I believe that his curiosity about the world, fueled by his belief in biblical creation [http://answersingenesis.org/creation/] , led to his discovery of bacteria. In a similar manner, his curiosity of blood led to his discovery of red corpuscles and capillaries. He remained a curious man until the last days of his life 300 years …

The Return Of Malaria To The Usa: Did God Create Parasites To Make Us Sick?, Alan L. Gillen

Faculty Publications and Presentations

Summer 2023, the Centers for Disease Control and Prevention reported several cases of locally acquired malaria in Florida, Texas, and Maryland, meaning that patients were infected within the US—the first such cases in over two decades (CDC 2023). The significance of the cases and how individuals and public health officials should respond to the situation is still unknown. The CDC is collaborating with state health departments on an investigation of seven locally acquired cases of Plasmodium vivax malaria in Sarasota County, Florida, and one case in Cameron County, Texas, and Maryland near Washington DC. There is no evidence to suggest …

Predicting Successful Completion Of Biology From Course Satisfaction And Curriculum Format For Nontraditional Students, Janet Elizabeth Forde

Doctoral Dissertations and Projects

The overall purpose of this study was to determine if there was a relationship between the biology curriculum design with student course satisfaction and the successful completion for nontraditional adult students. The current study was important in determining course curriculum format leading to nontraditional students’ successful course completion. The selected college is a small two-year community college in the southeast United States. This quantitative, predictive correlation study surveyed 85 nontraditional students’ satisfaction with the biology course curriculum format using the Online Course Satisfaction Scale. The survey data was correlated along with the type curriculum used in the course section (Open …

Molecular And Morphological Analyses Confirm That All Loons (Aves: Gaviiformes) Form A Single Holobaramin, Timothy R. Brophy, Mary-Clark A. Matthews, Mckayla M. Guillory, Alexis M. Ramerth

Faculty Publications and Presentations

Loons or divers (Aves: Gaviiformes), a group of waterbirds found primarily in the Northern Hemisphere, are comprised of several extinct taxa as well as an extant family (Gaviidae) with one genus (Gavia) and five species. Recent phylogenetic studies suggest that the Sphenisciformes (penguins) and Procellariiformes (petrels, albatrosses, and shearwaters) form a sister group to the loons. Our previous research, based on hybridization, morphological, and vocalization data, found that all extant loons form a single holobaramin (i.e., created kind). This previous study, however, was inconclusive as to the membership of fossil taxa within the kind. The goal of the present study …

Hybridization And Genetic Distances Suggest One Large Monobaramin In The Gourd Family (Cucurbitales: Cucurbitaceae), Timothy R. Brophy, Jack R. Gregory, Brigitte Townsend

Faculty Publications and Presentations

The gourds form a primarily tropical and subtropical family (Cucurbitales: Cucurbitaceae) of herbaceous climbers and woody lianas composed of approximately 960 species in 95 genera and 15 tribes. Many of these are globally important food crops and ornamentals including cucumbers, gourds, squashes, melons, pumpkins, and luffas. Utilizing published literature, there is evidence of interspecific hybridization (natural, experimental cross-pollination, and embryo/ovule culture) in five of the 15 tribes. These consist of successful crosses between 131 unique species pairs, including two intergeneric and one intertribal cross, forming eight monobaramins. In addition, species that do not hybridize directly, but hybridize with the same …

A New Spin On The Bacterial Flagellum: Its Normal Niche And Displacement, Alan L. Gillen

Faculty Publications and Presentations

Antoni van Leeuwenhoek observed individual living cells for the first time in history in 1674. Two years later, he noted microbes with long, thin appendages protruding from globular cells that seemed to provide locomotion, like “little feet” as they moved in drops of water. He gave credit to God in his writings over these new moving wonders. These appendages are now known as flagella (fig. 1), meaning “little whips” (from Latin).

More than 300 years later, Dr. Michael J. Behe used the flagellum and its nanomotor to introduce the concept of “irreducible complexity”—the idea that a structure is so complex …

Assessing The Effects Of Elevation On The Peaks Of Otter Salamander (Plethodon Hubrichti) Using Body Condition Index, Norman Reichenbach, Timothy R. Brophy, Hannah Suber, Elisabeth Russell, Hannah Kinsley, Liam Cusack, Cetia Dawson, Savannah Dunn, Olivia De Araujo

Faculty Publications and Presentations

The Peaks of Otter Salamander (Plethodon hubrichti; POS) is a montane species found at elevations above 442 m within a 117 km2 area of the Blue Ridge Mountains in central Virginia. In allopatric areas (areas without the Eastern Red-backed Salamander, P. cinereus, a known competitor), POS body condition was hypothesized to decline both above and below some optimal elevation. Decreased condition at lower elevations would most likely be due to increased temperatures and lower relative humidities, which may adversely affect the ability of salamanders to forage effectively on vegetation due to desiccation risk. Decreased condition at elevations above …

Why Are There So Many Mosquitoes?, Alan L. Gillen, Savannah Childs, Megan Goin, Karly Mckinney

Faculty Publications and Presentations

Mosquitoes have been challenging man and animals alike since the fall.Mosquitoes number in the trillions worldwide. Not only is the mosquito a nuisance with the constant buzz around your ear, they also are the primary vector of many dangerous diseases including the West Nile Virus (WNV). WNV has become a more prominent mosquito-transmitted disease in the United States and more specifically in Colorado, Texas, and other states in the Midwest. While commonly found in the genus Culex, WNV and other diseases can be found in differentgenera of mosquito, including Aedes and Anopheles. While these two are not themost common regarding …

Prevalence Of Bacillus Licheniformis On Northern Saw-Whet Owls (Aegolius Acadicus), Lauren Benedict

Senior Honors Theses

Birds are hosts to a variety of bacteria and fungi including some that are keratinolytic. These feather degrading bacteria, including Bacillus licheniformis, are capable of degrading β-keratin which is a major component of feathers. While there is little evidence to indicate that feather degrading bacteria are capable of degrading feathers on live birds, there is ample evidence to indicate that many bird species experience altered feather coloration. There is significant variation in the reported prevalence of B. licheniformis on birds with percentages ranging from 6.7% to 99%. This study sought to provide further support for an overall prevalence of …

The Effects Of Epistemic Beliefs On Undergraduate Students' Emotions And Attitudes Towards Genetically Modified Foods, David Andrew Lee

Doctoral Dissertations and Projects

Much research has explored socio-scientific issues (SSIs) in science instruction, including the connections between conceptions and attitude. Studies have also shown that epistemic beliefs affect epistemic emotions, which are a key component of students’ reaction to complex scientific topics. Correcting misconceptions can also result in emotional and attitude change, particularly surrounding the topic of genetically modified foods (GMFs). However, the impact of epistemic beliefs on emotions and attitude towards GMFs has largely gone unexplored. The purpose of this study is to examine the effects of epistemic beliefs on epistemic emotions and attitudes towards GMFs. This quantitative correlational study sampled 78 …

The Directed Steps Of Hans Christian Gram: How Providence Played A Role In The Gram Stain, Which Illumines The Ordered Pattern Of Bacterial Cell Walls And Helps Identify Pathogens Of Infectious Diseases, Alan L. Gillen

Faculty Publications and Presentations

This paper honors Hans Christian Joachim Gram. In published papers, he simply identified as Christian Gram. Gram devised a staining technique that is still used to identify and classify different types of bacteria. He was a Danish microbiologist, born in Copenhagen on September 13, 1853. In German microbiologist Karl Friedländer’s lab, Gram noticed that staining a smear of pneumonia bacteria with a crystal violet followed by iodine and organic solvent showed differences in various samples. “Gram-negative” bacteria have thin cell walls that allow the solvent to wash away part of the stain. “Gram-positive” bacteria appear purple in microscopy because their …

A Baraminological Analysis Of The Loons (Gaviiformes: Gaviidae) Reveals Their Holobaraminic Status, Timothy R. Brophy, Mary-Clark Matthews, Alexis Ramerth, Mckayla Guillory

Faculty Publications and Presentations

No abstract provided.

New Baraminological Methods Confirm Monobaraminic Status Of The Horses (Perissodactyla: Equidae) And Preliminary Analyses Of New Datasets Suggest The Possibility Of Discontinuity Between Horses And Various Outgroup Taxa, Timothy R. Brophy, Jack Gregory, Mary-Elizabeth Tallman, Kara Ray

Faculty Publications and Presentations

No abstract provided.

Population Ecology Of The Queensnake (Regina Septemvittata) In An Urban Creek, 2008 To 2019, Rachel Beiler, R. Elliot Miller, Norman Reichenbach

Faculty Publications and Presentations

Habitat fragmentation is a common result of urbanization and species living in these fragments are at risk of extirpation. We conducted a 12-y (2008–2019) capture-mark-recapture study on snakes living in a 593-m section of Rock Castle Creek flowing through an urban area in central Virginia, USA. Our study site was occupied primarily by Queensnakes (Regina septemvittata). We used data from 168 individual Queensnakes to examine several aspects of their population ecology including survival rates (0.52), reproductive effort (21.3% juvenile to adult ratio), growth rates (68% and 30.6% increase for 1 to 2 y-old and 2 to 3+ y-old snakes, respectively), …

The Origin Of Ticks And The Genesis And Emergence Of Lyme Disease, Alan L. Gillen, Matthew Eakin

Faculty Publications and Presentations

Ticks are notorious for their capability of transmitting diseases that have debilitated humanity for thousands of years. They can confer lifelong chronic ailments via pathogenic bacterial species that they harbor inside themselves. These parasitic tick species, namely the Ixodes scapularis tick is responsible for hundreds of thousands of Lyme disease infections each year. This profound tick continues to produce the highest rate of zoonotic disease in the United States each year. Many may ask why these tick species are so infectious when ticks were originally designed by a benevolent God. Why would a good Creator choose to design a creature …

Why New Diseases Keep Popping Up, Alan L. Gillen, Jason Conrad

Faculty Publications and Presentations

New and reemerging diseases are terrifying and concerning problems. Not only do they carry a financial and emotional toll, but they account for significant numbers of death. Emerging diseases are usually zoonotic and highly virulent in nature. These are pathogenic and parasitic diseases of high consequence and impact. Why would a good Creator allow these new diseases? Why do new diseases keep popping up? Mutation and displacement of original types of microbes account for many new diseases; however, the answer is more complex than just these two factors. Zoonoses are the most common type of infection, specifically from viral pathogens, …

Mrna Vaccinations For The Prevention Of Viral Infections, Isaac Underhill

Senior Honors Theses

mRNA vaccines for the prevention of infection disease have gained significant traction in the last three decades, specifically with the recent emergency approval of two COVID-19 vaccines (Oliver, Sara E et al., 2020; Rauch et al., 2018a). mRNA vaccines occupy a unique space in immunology because of their utilization of cellular mechanisms to produce viral proteins, and their simplicity and ease of manufacture (Cullis & Hope, 2017). These vaccines have shown strong humoral and cell-mediated adaptive immune responses (Rauch et al., 2018b) . In addition, side effects of the vaccines have been limited and subject response is manipulatable by varying …

A Baraminological Analysis Of The Landfowl (Aves: Galliformes), Timothy R. Brophy

Faculty Publications and Presentations

We performed a baraminological analysis on 60 extant landfowl taxa (Aves: Galliformes) using 102 morphological characters. Both baraminic distance correlation analysis and multidimensional scaling suggest the possibility of four holobaramins within the landfowl order: Megapodiidae, Cracidae, Numididae, and the remaining Phasianoidea. Hybridization, however, connects three of these holobaramins (six of the currently recognized families). Considering both sets of evidence, we conclude that the landfowl are composed of two holobaramins: Megapodiidae and [Phasianoidea + Cracidae]. The five currently recognized families in the superfamily Phasianoidea have, until recently, been considered subfamilies in a more broadly conceived family Phasianidae, so it should not …

Results Of Bdistmds And Barclay Are Generally Similar And Confirm Baraminological Conclusions For The Landfowl, Timothy R. Brophy

Faculty Publications and Presentations

Wood (2020a, b) recently introduced BARCLAY, a statistical baraminology web application designed to revise and replace BDISTMDS (Wood 2008). Revisions included use of Jaccard distances in addition to classical “baraminic distances,” replacement of parametric Pearson correlations with the nonparametric Spearman, and addition of medoid partitioning (PAM) and fuzzy analysis (FANNY) clustering techniques (Kaufman and Rousseeuw 1990). A BDISTMDS analysis of the landfowl (Aves: Gallifomes) suggested the possibility of four holobaramins within this order (Brophy and Mullis in press). Hybridization, however, connected three of these holobaramins and the authors ultimately concluded that the landfowl were composed of only two holobaramins (Megapodiidae …

Student Success Of Online Vs. In-Person Biology Courses At Virginia Community Colleges, Jennifer Claire Scott

Doctoral Dissertations and Projects

Community colleges have a significant role in preparing students for STEM-related careers through certificates, degrees, and transfers to four-year institutions. In addition, online education is a growing mode of higher education, particularly for community college students. However, community college and online students are both at a high risk of attrition and show a lower success rate for degree completion. The purpose of this study was to identify differences in attrition and success between students in online and in-person biology courses at Virginia community colleges. Also, this study addressed downstream effects of online education by examining course completion of second-semester biology …

A Microbiome Analysis Of The Relationship Among Crayfish Ectosymbionts And Their Environment, John Hoverson

Senior Honors Theses

The purpose of this project was to determine if there are differences present between the α-diversities of the crayfish microbiome and its surrounding water and sediment. Furthermore, this project sought to discover if these differences hold when microbiomes are evaluated between crayfish of first and second stream orders. Finally, this project sought to determine if the presence of branchiobdellidan ectosymbionts on the crayfish caused further differences in the crayfish microbiome. While the hypothesized patterns between crayfish, ectosymbionts, and stream order were not found to exist, a significantly different microbiome was observed between water, sediment, and crayfish, and the α-diversity of …

Dna Aptamer-Drug Targeting Chemotherapy: Investigation Of Cell Cycle Inhibition Via S15 Aptamer – Norcantharidin Complex, Shannon Fehr

Senior Honors Theses

Lung Cancer is the leading cause of cancer related death in both men and women in the United States (Bray et al., 2018). Cancer treatments are often non-specific and kill many dividing cells within a patient causing unwanted side effects. Norcantharidin (NCTD) is a synthetic FDA approved treatment for cancers including non-small cell lung cancers (NSCLC). NCTD suppresses cell proliferation by inhibiting cells from exiting the G2 phase of the cell cycle. Aptamers are short single-stranded DNA or RNA molecules with ligand directed self-annealing capabilities allowing selective binding to specific targets. This paper will discuss the hypothesized effects of using …

Investigation Of Undocumented Heart Disease In Cadaveric Donors, Crystal Danae Passburg

Doctoral Dissertations and Projects

For nearly a century, heart disease has been the leading source of death and disease in the United States, causing the deaths of hundreds of thousands of individuals every year and burdening millions more with diminished health and severe disability. However, despite the significant known prevalence of heart disease, studies suggest that many more individuals—and particularly those within the female and elderly populations—may possess undiagnosed heart disease which remains undetected even after death due to the lack of autopsy examination. In the absence of autopsy, many cases of heart disease may never be identified, resulting in a skewed understanding of …

The Genesis Of Sars-Cov-2 Virus And The Origin Of The Covid-19 Pandemic, Alan L. Gillen

Faculty Publications and Presentations

The current outbreak of the 2019 novel coronavirus (SARS-CoV-2, fig. 1), causing a respiratory-tract illness, first started in Wuhan, China, and has been escalating worldwide. The official disease name became known as COVID-19 in mid-spring 2020. It shares some characteristics of the SARS virus of 2002–3. Early on, with many cases in Wuhan, China, it was reported that the outbreak had some association with animal markets, which indicated that there was animal-to-person transmission. Like SARS-CoV-1, the suspected animal source of the virus is bats. We have not seen this virus before, and our bodies were not ready for this, nor …

Physiological And Molecular Outcomes Of Chronic Post-Weaning Folate Deficiency, Abigail Joan Lawton

Doctoral Dissertations and Projects

Folate is an essential B vitamin that serves as a primary one-carbon carrier in a number of essential cellular reactions; among these reactions are synthesis of purines, thymidylate, and methionine. As a result of these synthesis reactions, folate plays a key role in regulating nucleic acid metabolism, amino acid metabolism, maintenance of DNA stability, and production of S-adenosylmethionine for methylation of nucleic acids, neurotransmitters, phospholipids, histones, and other proteins. As such, folate deficiency is associated with a number of adverse outcomes including various cancers, cardiovascular disease, and cognitive defects. Despite mandatory folate fortification in grains in many developed countries, a …

Possible Roles For Essential Oils In Chemoprevention And Suppression Of Cancer, Chad Kirk Lillestolen

Senior Honors Theses

Cancer represents one of the costliest and most prevalent diseases to afflict the modern world, even though treatments have evolved steadily over the years and produce an increasingly positive outlook with each development and innovation. Essential oils have been used medicinally- among other purposes- for thousands of years and have begun to attract attention for possible applications to the field of oncology. Numerous investigations and publications have shed light on the possible chemopreventative (antioxidant and antimetastatic) uses of these oils, alongside cancer suppressive (apoptosis-inducing and cytotoxic) abilities that they may possess. With the high annual incidence of cancer and the …

Wise Blood: Antibodies, The Principle Of Overcoming In Disease (Part 2), Alan L. Gillen, Keoprommony Huy

Faculty Publications and Presentations

No abstract provided.