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Oxidative Stress In Oocytes During Midprophase Induces Premature Loss Of Cohesion And Chromosome Segregation Errors, Adrienne T. Perkins, Thomas M. Das, Lauren C. Panzera, Sharon E. Bickel
Oxidative Stress In Oocytes During Midprophase Induces Premature Loss Of Cohesion And Chromosome Segregation Errors, Adrienne T. Perkins, Thomas M. Das, Lauren C. Panzera, Sharon E. Bickel
Dartmouth Scholarship
In humans, errors in meiotic chromosome segregation that produce aneuploid gametes increase dramatically as women age, a phenomenon termed the "maternal age effect." During meiosis, cohesion between sister chromatids keeps recombinant homologs physically attached and premature loss of cohesion can lead to missegregation of homologs during meiosis I. A growing body of evidence suggests that meiotic cohesion deteriorates as oocytes age and contributes to the maternal age effect. One hallmark of aging cells is an increase in oxidative damage caused by reactive oxygen species (ROS). Therefore, increased oxidative damage in older oocytes may be one of the factors that leads …
The Fast-Evolving Phy-2 Gene Modulates Sexual Development In Response To Light In The Model Fungus Neurospora Crassa, Zheng Wang, Ning Li, Jigang Li, Jay C. Dunlap, Frances Trail, Jeffrey P. Townsend
The Fast-Evolving Phy-2 Gene Modulates Sexual Development In Response To Light In The Model Fungus Neurospora Crassa, Zheng Wang, Ning Li, Jigang Li, Jay C. Dunlap, Frances Trail, Jeffrey P. Townsend
Dartmouth Scholarship
Rapid responses to changes in incident light are critical to the guidance of behavior and development in most species. Phytochrome light receptors in particular play key roles in bacterial physiology and plant development, but their functions and regulation are less well understood in fungi. Nevertheless, genome-wide expression measurements provide key information that can guide experiments that reveal how genes respond to environmental signals and clarify their role in development. We performed functional genomic and phenotypic analyses of the two phytochromes in Neurospora crassa, a fungal model adapted to a postfire environment that experiences dramatically variable light conditions. Expression of phy-1 …