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The Role Of Ceruloplasmin In Colitis, Bakytzhan Bakhautdin
The Role Of Ceruloplasmin In Colitis, Bakytzhan Bakhautdin
ETD Archive
Ceruloplasmin (Cp) is an acute phase, plasma protein with multiple enzymatic activities consistent with both pro- and anti-inflammatory functions. Our laboratory has recently reported the presence of Cp in intestinal epithelial cells. To determine the potential role of Cp in intestinal inflammation, we induced colitis in Cp-deficient mice by continuous administration of dextran sodium sulfate (DSS) ad libitum in the drinking water. The Cp-null mice rapidly lost weight and all were moribund by day 14, while about 90 of the wild-type (WT) mice survived at least 20 days. Higher amounts of TNF-alpha, and neutrophil (KC) and macrophage (MCP-1) chemokines, were …
The Role Of Sigirr In Innate And Adaptive Immunity, Muhammet Fatih Gulen
The Role Of Sigirr In Innate And Adaptive Immunity, Muhammet Fatih Gulen
ETD Archive
Single immunoglobulin IL-1R-related receptor (SIGIRR) is a transmembrane protein, which belongs to interleukin 1 receptor (IL-1R)/Toll like receptor (TLR) superfamily (Toll-IL-1R superfamily). SIGIRR has been identified as a negative modulator for IL-1R/TLR signaling. Recently, detailed structural and functional analysis of SIGIRR has been published, however physiological function of SIGIRR has not been studied. To asses the physiological function of SIGIRR, the expression of SIGIRR mRNA in different mouse tissues was analyzed. Although SIGIRR is expressed in many tissues, its expression in different cell types was more restricted, with extremely high expression in primary kidney, colon epithelial cells and T cells, …