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A Comparison Of Hsp70 Expression And Thermotolerance In Adults And Larvae Of Three Drosophila Species, Robert A. Krebs
A Comparison Of Hsp70 Expression And Thermotolerance In Adults And Larvae Of Three Drosophila Species, Robert A. Krebs
Biological, Geological, and Environmental Faculty Publications
Heat shock proteins (Hsps) and other molecular chaperones perform diverse physiological roles. One is to facilitate, in part, organismal thermotolerance, of which the functional consequences depend on Hsp70 concentration and developmental stage in Drosophila melanogaster. To test whether an Hsp70-thermotolerance relationship is a general phenomenon within Drosophila, I assayed Hsp70 concentration at a range of temperatures in intact larvae and adults of three species, D. melanogaster, D. simulans, and D. mojavensis, and compared those results to the increase in survival to heat shock that occurs after an Hsp70 inducing pretreatment. Larvae of D. melanogaster and D. simulans responded similarly to …
A Genetic Analysis Of The Relationship Between Life-History Variation And Heat-Shock Tolerance In Drosophila Buzzatii, Robert A. Krebs, Volker Loeschcke
A Genetic Analysis Of The Relationship Between Life-History Variation And Heat-Shock Tolerance In Drosophila Buzzatii, Robert A. Krebs, Volker Loeschcke
Biological, Geological, and Environmental Faculty Publications
Although exposure to environmental stress is common in most populations, and the physiological effects of stress on individuals are well studied, the evolutionary importance of stress to populations is not well understood. To address multitrait responses to environmental change and potential constraints on character evolution, we analysed, in 100 isofemale lines of Drosophila buzzatii, the genetic relationships between resistance to a short heat shock and several life-history traits: survival in benign conditions, larval developmental time, fecundity and longevity. Estimates of heritability of larval thermotolerance were low, but significant, and all life-history traits varied significantly among isofemale lines. Several of …
Evolution Of Thermotolerance And Variation In The Heat Shock Protein, Hsp70, Robert A. Krebs, Brian R. Bettencourt
Evolution Of Thermotolerance And Variation In The Heat Shock Protein, Hsp70, Robert A. Krebs, Brian R. Bettencourt
Biological, Geological, and Environmental Faculty Publications
Low to moderate levels of stress induce a class of molecular chaperones called heat shock proteins (Hsps), which protect cells, tissues and whole organisms from more severe stress. In higher Eukaryotes, Hsp70 is one of the principle heat-induced chaperones. This response is general, and how much Hsp70 an animal produces correlates with the level of stress to which it is exposed. Nonetheless, definitively linking high Hsp70 expression as an adaptation to stress tolerance is problematic, because organisms and cells respond to stress in many ways. By molecular manipulation of Hsp70 in one animal group, Drosophila, differences in hsp70 copy number …