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- Glioblastoma (3)
- Anticancer (2)
- Arylidene (2)
- Heterocyclic (2)
- Arylidenes (1)
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- Biofumigation (1)
- Cancer (1)
- Docosahexaenoic Acid (1)
- Florida Manatees (1)
- Gene Expression (1)
- Glioblastoma multiforme; Antineoplastic agents; Brain--Cancer; Arylidene (1)
- Heterocyclic compounds; Glioblastoma multiforme; Antineoplastic agents (1)
- Manatees; Teeth--Abrasion (1)
- Mustard Seed (1)
- Omega-3 (1)
- Omega-3 fatty acids; Docosahexaenoic acid; Gene expression; Saccharomyces cerevisiae (1)
- Pyrazolone (1)
- Pyrazolones; Glioblastoma multiforme; Antineoplastic agents (1)
- Sacharomyces Cerevisiae (1)
- Teeth Wear (1)
- Velvetleaf (1)
- Weed (1)
- Weeds--Control; Mustard--Seeds; Biofumigation; Velvetleaf--Biological control (1)
Articles 1 - 6 of 6
Full-Text Articles in Biology
The Effects Of The Omega-3 Fatty Acids Docosahexaenoic Acid On Inm1 Gene Expression In Saccharomyces Cerevisiae, Haley Kang
Honors Theses
Bipolar disorder is a mental disorder associated with abnormal inositol levels. Preliminary studies show omega-3 fatty acids alter intracellular inositol levels; however, the cellular mechanism behind this process is unknown. Therefore, the focus of this study is to determine the effects of the omega-3 fatty acid docosahexaenoic acid (DHA) on the expression of INM1 which encodes inositol monophosphatase. Using yeast as our model system, cells were grown in varying concentrations DHA and the expression on INM1 was determined by RT-qPCR. The results show INM1 expression increased with increasing concentrations of DHA; thus, the effects of DHA on inositol levels may …
Novel Heterocyclic Arylidene Derivatives As Anticancer Agents Against U87 Human Glioblastoma, Benjamin H. Hiramoto
Novel Heterocyclic Arylidene Derivatives As Anticancer Agents Against U87 Human Glioblastoma, Benjamin H. Hiramoto
Honors Theses
The primary objectives of this interdisciplinary study were the synthesis of novel heterocyclic arylidenes and the investigation of their anticancer activity against U87 glioblastoma cell viability. Recently, novel hybrid derivatives have been considered as potential candidates for treating glioblastoma, demonstrating a synergistic anticancer effect in previous studies. 12 heterocyclic arylidenes with various functional groups, including halogens and boronic acid, were produced via a Knoevenagel condensation. These compounds and their starting reagents were then administered to U87 glioblastoma cancer cells at graded concentrations within a 12-well cell viability assay to determine each compound’s lethal concentration 50 (LC50). The LC50 of each …
Are Florida Manatees (Trichechus Manatus Latirostris) Wearing Their Teeth Beyond Functionality? Interspecific And Intraspecific Mesowear In Manatees, Nina Woodard
Honors Theses
Manatees (Trichechus spp.) are herbivorous aquatic mammals found in tropical and subtropical waters. At maturity, they possess only supernumerary molars (SM), with 5-8 in occlusion at each quadrant. Manatees exhibit a dental replacement system in which they shed old teeth anteriorly and erupt new teeth posteriorly. This adaptation is thought to have arisen to deal with abrasive foods. Mesowear (facet development on occlusal surfaces of teeth) increases from posterior (younger) to anterior (older) molars. Tooth functionality is linked to level of mesowear, with increased amounts resulting in decreased food-processing ability. Less functional teeth can result in an increase in feeding …
Synthesis Of An Arylidene Pyrazolone And Its Effects On Glioblastoma Cancer Cells, Joanna Deonarine
Synthesis Of An Arylidene Pyrazolone And Its Effects On Glioblastoma Cancer Cells, Joanna Deonarine
Honors Theses
The purpose of this research is to develop a new technique to synthesize a heterocyclic arylidene compound using fruit puree catalysis and investigate its anti-cancer activity on glioblastoma cancer cells. Recently, there has been interest in heterocycles due to their anticancer properties and they have been used in almost two-thirds of the novel molecular anticancer agents. Varying fruit purees were used to synthesize a novel hybrid arylidene pyrazolone from 3-methyl-1-phenyl-5-pyrazolone and 4-dimethylaminobenzaldehyde by modifying methodology developed by Dr. Murray. This arylidene pyrazolone was then tested for its anticancer activity on glioblastoma brain cancer cells using Dr. Smith’s 12-well cell viability …
Evaluation Of Anticancer Activity Of Heterocyclic Arylidenes On The U87mg Cancer Cell Line, Bernadette Flores
Evaluation Of Anticancer Activity Of Heterocyclic Arylidenes On The U87mg Cancer Cell Line, Bernadette Flores
Honors Theses
Glioblastoma multiforme, is a type of brain cancer that develops from glial cells, which surround neurons and provide support and insulation. Previous investigation has shown that some heterocyclic compounds are key in improving the properties of anticancer drugs by enhancing lipophilicity, polarity, and other varying physiochemical features. Synthetic heterocyclic compounds used as anticancer drugs attempt to imitate naturally-occurring ligands and substrates so as to disturb the natural balance in cells. Testing was done to determine the anticancer abilities of hybrid compounds, heterocyclic arylidenes, containing various functional groups, including boronic acids, through a three-day testing process. These compounds were previous synthesized …
Exploring Soil Texture Effects On Mustard Seed Meal Suppression Of The Weed Velvetleaf, Daheun Danielle Harning
Exploring Soil Texture Effects On Mustard Seed Meal Suppression Of The Weed Velvetleaf, Daheun Danielle Harning
Honors Theses
The use of mustard seed meal (MSM) as a biofumigant in managing weeds in agricultural settings has been well documented. Previous work with MSM has shown that soils with a higher sand content were better at weed suppression than soils with lower amounts of sand. It was hypothesized that the elevated sand content created more air space for volatile inhibitory compounds to diffuse and inhibit seed germination and growth. Although initial results from bioassays systematically testing the comparison of 5 differing levels of sand showed support for this hypothesis, further testing with micron-sized glass beads showed that loss of airspace …