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Nanochromosome Copy Number Does Not Correlate With Rna Levels Though Patterns Are Conserved Between Strains Of The Ciliate Morphospecies Chilodonella Uncinata, Jie Huang, Laura A. Katz
Nanochromosome Copy Number Does Not Correlate With Rna Levels Though Patterns Are Conserved Between Strains Of The Ciliate Morphospecies Chilodonella Uncinata, Jie Huang, Laura A. Katz
Biological Sciences: Faculty Publications
In some ciliates, extensive genome fragmentation leads to a macronucleus (i.e. somatic nucleus) containing gene-sized chromosomes that vary in copy number. Yet the relationship between copy number and expression level is not well understood as previous work has shown a variety of patterns. For example, nanochromosome copy numbers are positively correlated to mRNA levels in spirotrichous ciliates, while one study of Chilodonella uncinata suggested that they were inversely correlated. To study further copy number and expression levels in C. uncinata, we analyzed 11 members in five gene families (SSU-rDNA, actin, alpha-tubulin, histidine acid phosphatase family protein and a protein kinase …