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Articles 1 - 3 of 3
Full-Text Articles in Biology
The Dysregulation Of Circadian Rhythms And Its Relation To Hippocampal Neurodegenerative Disease, John Patrick Mccauley
The Dysregulation Of Circadian Rhythms And Its Relation To Hippocampal Neurodegenerative Disease, John Patrick Mccauley
Legacy Theses & Dissertations (2009 - 2024)
Circadian rhythms modulate body temperature, sleep-wake cycles and cognitive functions like learning and memory. Interestingly, patients suffering from neurodegenerative disease like Alzheimer’s disease and brain insults like traumatic brain injury experience dysregulated circadian rhythms and learning and memory deficiencies as a symptom. The core molecular machinery that establishes these rhythms relies on the activation of positive and negative transcriptional-translational feedback loops within the hypothalamic suprachiasmatic nucleus (SCN). Subordinate circadian oscillators distributed throughout the peripheral and central nervous system follow the rhythmic activity of the SCN. One of these, the hippocampus, is mostly involved in regulating memory formation and recall. Experimental …
Role Of Smad4 Dependent Signaling In Controlling The Functioning And Connectivity Of Basal Vomeronasal Sensory Neurons, Ankana S. Naik
Role Of Smad4 Dependent Signaling In Controlling The Functioning And Connectivity Of Basal Vomeronasal Sensory Neurons, Ankana S. Naik
Legacy Theses & Dissertations (2009 - 2024)
ABSTRACT
Effect Of Draxin Manipulation On Btbr Mouse Brain And Behavior, Adam Blau
Effect Of Draxin Manipulation On Btbr Mouse Brain And Behavior, Adam Blau
Legacy Theses & Dissertations (2009 - 2024)
Autism Spectrum Disorder (ASD) is known for distinct behavioral phenotypes such as a preference for repetitive activities and difficulty in socialization. However, little is known about what might cause ASD. Current evidence implicates genetics as playing a substantial role in ASD. Mouse models, such as BTBR T+ Itpr3tf/J (BTBR) inbred mice, are an invaluable resource for ASD research, as they allow the investigation of both genetics and behavior in parallel. BTBR mice are of interest due to their reduced hippocampal commissure (HC) and absent corpus callosum (CC), along with increased exploratory activity, decreased anxiety, reduced sociability, and increased repetitive self-grooming …