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The Characterization Of The Type I Dna Methyltransferase Hsdm1 (Hp0463) In Helicobacter Pylori, Elise Zimmerman
The Characterization Of The Type I Dna Methyltransferase Hsdm1 (Hp0463) In Helicobacter Pylori, Elise Zimmerman
Undergraduate Honors Theses
Helicobacter pylori is a gram-negative spiral-shaped bacterium that colonizes the gastric epithelium and is the leading cause of gastric adenocarcinoma globally. For both H. pylori and many other bacterial species, there is an increasing body of evidence that methylation by restriction-modification systems regulates gene expression in addition to its traditional role in genome protection. The study aimed to further elucidate the mechanisms through which H. pylori achieves methylome plasticity. We demonstrated that the Type I DNA methyltransferase hsdM1 (HP0463) is regulated by the main acid sensing mechanism of H. pylori, the two-component system (TCS) ArsRS. ArsRS induces hsdM1 …