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Articles 1 - 6 of 6
Full-Text Articles in Biology
Ohio Anuran Gut Microbiomes, Serena Hoffman
Ohio Anuran Gut Microbiomes, Serena Hoffman
Undergraduate Honors Thesis Projects
Recent studies focusing on the skin and gut microbiome of vertebrates have found how important microbiomes are to maintaining host health. Understanding the role the gut microbiome plays to host health is of great importance for conservation. Less is known about the gut microbiome than the skin microbiome for amphibians. Literature is especially lacking for local Ohio anuran species. The purpose of this study was to establish the baseline composition of the gut microbiome for local Ohio anurans and to determine whether host species or habitat is the best predictor of gut microbiome composition. Tadpoles were collected from seven different …
Antimicrobial Properties Of An Unknown Microorganism Isolated From The Local Environment, Danielle Duryea
Antimicrobial Properties Of An Unknown Microorganism Isolated From The Local Environment, Danielle Duryea
Undergraduate Honors Thesis Projects
Bacterial species that cause disease can usually be combatted with antibiotics; but as the years pass, more and more bacterial pathogens are becoming resistant to these treatments. In fact, the Center for Disease Control has identified eighteen classes of bacteria ranging from urgent to concerning threats due antibiotic resistance (2019), warning the advance of an antibiotic resistance crisis in which untreatable bacterial infections will become a leading cause of death (Bennadi, 2014). The Small World Initiative is a program created in 2012 at Yale University to address the antibiotic crisis through a crowdsourcing effort where undergraduate students are encouraged to …
Life Line March 2020, Otterbein Biology And Earth Science Department
Life Line March 2020, Otterbein Biology And Earth Science Department
Life Line - The Biology Department Newsletter
The Department Welcomes Dr. Sinn; Modeling to Help with Global Research; The Paradise of Bombs Revisited; The End of an Era in Conesville Ohio; Reports from two recipients of the Melinda Phinney Award for Pre-Med Travel Experiences; Preparing Skins for Study; Genomics in the Jungle; Zoo Program Gets New T -Shirt and Sweatshirt Designs; Aquarium Track Dives Right In; Dr. Svitana’s Sabbatical Accomplishments;Biology Behind Bars; Grossology: The Science of Icky, Sticky, Disgusting Things.
Characterization Of Two Cyclic Di-Gmp Phosphodiesterases Hypothesized To Regulate Virulence In Streptomyces Scabies, Madison Flasco
Characterization Of Two Cyclic Di-Gmp Phosphodiesterases Hypothesized To Regulate Virulence In Streptomyces Scabies, Madison Flasco
Undergraduate Honors Thesis Projects
Common scab is a devastating disease that affects the marketability of potatoes. The disease results in raised and pitted lesions seen on the surface of the potato and is caused by the soil pathogen, Streptomyces scabies. The S. scabies genome has two cyclic-di-GMP phosphodiesterases, RmdA and RmdB, both regulators of morphology and development. These proteins break down the ubiquitous second messenger molecule cyclic di-GMP, a molecule in charge of cell cycle progression and virulence. Both proteins contain diguanylate cyclase domains and phosphodiesterase domains, GGDEF and EAL, respectively, while RmdA contains an additional PAS_4 domain. Despite similar domain configurations, the two …
Determination Of Cyclic-Di-Gmp- Controlled Gene Expression In A Pharmacologically Important Bacterium, Morgan A. Stark
Determination Of Cyclic-Di-Gmp- Controlled Gene Expression In A Pharmacologically Important Bacterium, Morgan A. Stark
Undergraduate Honors Thesis Projects
The second messenger molecule cyclic dimeric GMP (c-di-GMP) regulates a myriad of processes in gram-negative bacteria. However, less is known about the roles it plays in gram-positive bacteria. Differential gene expression in three strains of the gram-positive bacterium, Streptomyces coelicolor, is being studied using RNA sequencing and Real Time PCR to gain insight into c-di-GMP signaling. The rmdA rmdB (regulator of morphology and development) double mutant was compared to the wild type strain known as MT1110. The rmdA and rmdB genes are needed for the formation of aerial mycelium, an important step in the life cycle of Streptomyces coelicolor (Hull …
Cyclic Di-Gmp Phosphodiesterases Rmda And Rmdb Are Involved In Regulating Colony Morphology And Development In Streptomyces Coelicolor. Journal Of Bacteriology, Travis D. Hull, Min-Hyung Ryu, Matthew J. Sullivan, Ryan C. Johnson, Nikola T. Klena, Robert M. Gelger, Mark Gomelsky, Jennifer A. Bennett
Cyclic Di-Gmp Phosphodiesterases Rmda And Rmdb Are Involved In Regulating Colony Morphology And Development In Streptomyces Coelicolor. Journal Of Bacteriology, Travis D. Hull, Min-Hyung Ryu, Matthew J. Sullivan, Ryan C. Johnson, Nikola T. Klena, Robert M. Gelger, Mark Gomelsky, Jennifer A. Bennett
Biology and Earth Science Faculty Scholarship
Cyclic dimeric GMP (c-di-GMP) regulates numerous processes in Gram-negative bacteria, yet little is known about its role in Gram-positive bacteria. Here we characterize two c-di-GMP phosphodiesterases from the filamentous high-GC Gram-positive actinobacterium Streptomyces coelicolor, involved in controlling colony morphology and development. A transposon mutation in one of the two phosphodiesterase genes, SCO0928, hereby designated rmdA (regulator ofmorphology and development A), resulted in decreased levels of spore-specific gray pigment and a delay in spore formation. The RmdA protein contains GGDEF-EAL domains arranged in tandem and possesses c-di-GMP phosphodiesterase activity, as is evident from in vitro enzymatic assays using the purified protein. …