Biology Commons^™

Pvsripo Effect On Cancer, Vishal Jindal, Matthew Lee, Darshan Rola, Mir Saleem

Biology Faculty Articles

PVSRIPO, a variant of the poliovirus, is a revolutionary virus that demonstrates key characteristics for oncolytic virotherapy due to its ability to attack glioblastomas. The first criteria that PVSRIPO demonstrates is tumor-targeting tropism. PVSRIPO binds to nectin-like molecule 5 (Necl-5), a poliovirus receptor (PVR), found on different types of cancers such as lung cancer, colorectal cancer, and glioblastomas. This allows the virus to have a high binding affinity to tumor cells. Secondly, after modifying the poliovirus by substituting its internal ribosome entry site (IRES) with the Human Rhinovirus 2's (HRV2) IRES, the poliovirus becomes PVSRIPO, an attenuated version of the …

Cleveland Clinic Florida - Summer Scholar Program, Marina Handal

Trick to the Treat of Internships and Research

Program Overview:

• Cleveland Clinic Florida’s Summer Scholar Program is designed to allow students to gain shadowing experience in the medical field via the clinical and hospital settings.
• Students are assigned 3 rotations total within the 6-week span of the program; high school assignments run for a total of 3 weeks.
• Rotations include Internal Medicine, Cardiology, Neurosurgery, ICC, Emergency Medicine, and various other subspecialties.
• Students can expect to be at the Weston hospital Monday-Friday 8 am- 5 pm (varies based on rotation/clinic hours/surgery schedule).
• Attend weekly lectures that consist of discussion of the ethics of medicine, educational path to becoming a …

Medical University Of Graz - Summer Internship 2018, Nada Belal

Trick to the Treat of Internships and Research

Program Overview:

• Assist a transplant team at Medical University of Graz for 6 weeks
• Mainly general surgery and transplantation procedures, but can observe and assist in other types of operations, as well.
• Great opportunity to apply all that you have learned in the classroom through hands-on experience.

Cleveland Clinic Summer Scholar Program, Mahnoor Asif

Trick to the Treat of Internships and Research

Program Overview:

• The program lasts a total of 6 weeks, and you rotate through 3 different departments
• Dress code: Business professional attire + Cleveland Clinic white coat
• Every day will be different in terms of activity and length depending on your rotation site, if you have to do rounds, how early your first patient is coming into the clinic, etc. However, an average day will be from 8:30 a.m. - 5:30 p.m.

The University Of Texas Md Anderson Cancer Center - Biology Summer Internship, Marla Fortoul

Trick to the Treat of Internships and Research

Program Overview:

• 10 week program
• MD Anderson Cancer Center in Houston, Texas
• Students will be matched with a faculty mentor in any number of areas of biomedical research where a project will be assigned.
• Participants work alongside the mentor in a lab or clinic on projects designed by faculty to reflect current research.
• Workshops and lectures provide opportunities to connect with faculty, residents, postdoctoral and clinical fellows, and other participants.
• Through the program, students assess goals related to careers in oncology research and patient care.
• Symposium in which participants present talks and posters on their research projects to peers and …

Ussouthcom's Office Of The Command Surgeon - Pathway Internship Experience, Alexander Jakub Martinek

Trick to the Treat of Internships and Research

Program Overview: The Office of the Command Surgeon enables and synchronizes health engagement activities utilizing the whole of government approach to enhance regional health preparedness and increase our partner nations’ military and security forces’ medical capabilities.

Protein Modeling, Alesa Chabbra

Trick to the Treat of Internships and Research

Program Overview:

• The program is designed to answer the question "How can modeling using protein visualization software and 3D printing best demonstrate links between protein structure and function?"
• Done in collaboration with CREST and Center for BioMolecular Modeling

Science Alive, Allan Barraza, Ahjay Bhatia, Gwen Bui, Sophia Nguyen

Trick to the Treat of Internships and Research

Program Overview:

• Introduces STEM concepts to young students
• Encourage their pursuit of higher education
• Be role models
• Make friends

Cleveland Clinic Summer Scholars Program, Vanessa Cruise

Trick to the Treat of Internships and Research

Program Overview:

• Currently available to: High school juniors going into senior year and pre-med college freshmen that have completed their first year of college
• College freshman program is a 6 week program (3 rotations, 2 weeks long each). Rotations can be aligned with your preferred specialties if resources allow.

Practicum In Biology I: Gastroenterology Site, Roksana Hesari

Trick to the Treat of Internships and Research

Program Overview:

• Instructor - Dr. Mark Jaffe, DPM
• Didactic and experiential learning in applied settings
• Primary research literature exposure in field of interest
• Weekly face-to-face lectures for three hours
• Practicum site shifts for minimum 5 hours weekly
• Partnerships with Alvin Sherman Library and Career Services Department

Osteogenesis Of Dental Stem Cells, Jerry Ennolikara

Trick to the Treat of Internships and Research

Program Overview:

• This research lab is dedicated to the study of bioengineering bone tissue, an application of biology research within medicine known as "regenerative medicine," through a variety of in-vivo and in-vitro projects.
• The primary focus of our lab is to replace a lifetime of bone graft surgeries associated with cleft palate, a congenital disorder where the palatal process of the maxilla fails to fuse during development, with a noninvasive injectable treatment.
• The lab upholds the central motif of tissue engineering of "cells, scaffolds, and growth factors" with our research utilizing periodontal ligamental stem cells/human gingival mesenchymal stem cells; 3D …

Role Of Genes In Obesity, Hanna Mathew, Mir Saleem

Biology Faculty Articles

Obesity is the outcome of an extreme difference between the energy intake and the energy expended, which leads to severe weight gain. The two main factors of obesity are environmental influences and genetics, but the extent of the genetic contribution to obesity continues to be unknown. Multiple studies using different tools have been used to support the significance of the genetic influence on obesity, such as twin and adoption studies, race/ethnicity, and mouse models. The use of mouse models has allowed for the greatest expansion of knowledge on the genetics behind obesity, and advancements continue to be made to this …

Analytical “Bake-Off” Of Whole Genome Sequencing Quality For The Genome Russia Project Using A Small Cohort For Autoimmune Hepatitis, Daria V. Zhernakova, Sergei Kliver, Nikolay Cherkasov, Gaik Tamazian, Mikhail Rotkevich, Ksenia Krasheninnikova, Igor Evsyukov, Sviatoslav Sidorov, Pavel Dobrynin, Andrey A. Yurchenko, Valentin Shimansky, Irina V. Shcherbakova, Andrey S. Glotov, David L. Valle, Minzhong Tang, Emilia Shin, Kathleen B. Schwarz, Stephen James O'Brien

Biology Faculty Articles

A comparative analysis of whole genome sequencing (WGS) and genotype calling was initiated for ten human genome samples sequenced by St. Petersburg State University Peterhof Sequencing Center and by three commercial sequencing centers outside of Russia. The sequence quality, efficiency of DNA variant and genotype calling were compared with each other and with DNA microarrays for each of ten study subjects. We assessed calling of SNPs, indels, copy number variation, and the speed of WGS throughput promised. Twenty separate QC analyses showed high similarities among the sequence quality and called genotypes. The ten genomes tested by the centers included eight …

Periodontitis In Patients With Type 2 Diabetes Mellitus, Simran Agarwal, Deepthi Gangaram, Mir Saleem

Biology Faculty Articles

Periodontitis is a chronic, inflammatory disease that is characterized by swollen gums, degradation of jaw structure, and potentially tooth loss. Like Periodontitis, Type 2 Diabetes Mellitus is also highly prevalent and largely multifactorial. Type 2 Diabetes is a condition in which higher than normal blood glucose levels cannot be properly maintained as the body’s normal mechanism of maintaining proper blood glucose levels, the release of insulin from pancreatic islet β-cells, becomes ineffective. The purpose of this literature review is to explore the relationship between the incidences of Periodontitis and Type 2 Diabetes. The risk that Type 2 Diabetes poses for …

Neuropsychiatric Aspects Of Near-Death Experience, Jerod Buchta, Mir Saleem

Biology Faculty Articles

Throughout human history, there have been numerous reports of a baffling process when individuals have come to the brink of death. This process, referred to as near death experiences (NDEs), cause an individual to experience events that even the most advanced science can still not answer. This review serves as a reference for the factors, phenomenology, and measurement techniques for near death experiences as well as summarizing these experiences in certain conditions, such as cardiac arrest and admission of anesthetics. Discussed are the theories, effects, analyses of specific processes involved pertaining to experiences of those who walked along the edge …

Pulmonary Alveolar Proteinosis- A Case Report, Renee M. Horner, Douglas S. Gardenhire, Ralph D. Zimmerman

Internet Journal of Allied Health Sciences and Practice

ABSTRACT

Background: Pulmonary Alveolar Proteinosis (PAP) is a rare pulmonary disorder caused by a congregation of excessive lipoproteinaceous material in the alveolar spaces due to impaired surfactant metabolism. The congregation of the protein in the alveolar space leads to difficulty in breathing, impaired pulmonary immunity, and susceptibility to both opportunistic and acquired pulmonary infections. Although Pulmonary Alveolar Proteinosis is rare, there are potential treatments. Whole-lung lavage is the most widely accepted therapy and course of treatment. An additional form of therapy, GM-CSF stimulating therapy, uses recombinant deoxyribonucleic acid (DNA) technology to increase white cell production.

Purpose: The purpose …