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Articles 1 - 6 of 6
Full-Text Articles in Biology
Synthetic Viral Pyrogen Induces Behavioral Fever In Plethodon Glutinosus Salamanders, Nicholas Britt
Synthetic Viral Pyrogen Induces Behavioral Fever In Plethodon Glutinosus Salamanders, Nicholas Britt
Undergraduate Honors Theses
Behavioral fever is an essential coping mechanism across ectothermic phyla to aid in combating pathogenic threats. Ectotherms lack internal temperature regulation associated with fever in endotherms; thus, ectotherms can exhibit a behavioral fever response when immunocompromised to thermoregulate by moving to warmer locations. The salamander order Caudata, tend to be keystone species in their resident ecosystems through their role as secondary consumers of invertebrates to maintain the food chain. With growing interest about ecology and conservation of salamanders as species diversity declines, this study was designed to determine if salamanders use their environment to take advantage of behavioral fever. The …
Use Of Lymesim 2.0 To Assess The Potential For Single And Integrated Management Methods To Control Blacklegged Ticks (Ixodes Scapularis; Acari: Ixodidae) And Transmission Of Lyme Disease Spirochetes, Shravani Chitineni, Elizabeth R. Gleim, Holly D. Gaff
Use Of Lymesim 2.0 To Assess The Potential For Single And Integrated Management Methods To Control Blacklegged Ticks (Ixodes Scapularis; Acari: Ixodidae) And Transmission Of Lyme Disease Spirochetes, Shravani Chitineni, Elizabeth R. Gleim, Holly D. Gaff
Undergraduate Honors Theses
Annual Lyme disease cases continue to rise in the U.S. making it the most reported vector-borne illness in the country. The pathogen (Borrelia burgdorferi) and primary vector (Ixodes scapularis; blacklegged tick) dynamics of Lyme disease are complicated by the multitude of vertebrate hosts and varying environmental factors, making models an ideal tool for exploring disease dynamics in a time- and cost-effective way. In the current study, LYMESIM 2.0, a mechanistic model, was used to explore the effectiveness of three commonly used tick control methods: habitat-targeted acaricide (spraying), rodent-targeted acaricide (bait boxes), and white-tailed deer targeted acaricide (4-poster …
Analysis Of Genetic Structure And Pathogen Dynamics Of Ixodes Scapularis In Southwestern Virginia, Leemu Jackson
Analysis Of Genetic Structure And Pathogen Dynamics Of Ixodes Scapularis In Southwestern Virginia, Leemu Jackson
Undergraduate Honors Theses
Ixodes scapularis, or the blacklegged tick, is the primary vector of Borrelia burgdorferi. This pathogen is the causative agent of Lyme disease, the most common vector-transmitted disease in the United States. Although I. scapularis is distributed throughout the eastern U.S., Lyme disease is only considered endemic in the northeastern region of the country. Prior to 2007, Lyme disease was uncommon in Virginia, but since then cases of Lyme disease have increased dramatically with a hotspot forming in the Roanoke-Blacksburg area. The purpose of the current study was to determine whether B. burgdorferi prevalence and the genetic structure of I. …
Ticks On Lizards: Parasite-Host Interactions Of The Southern Alligator Lizard (Elgaria Multicarinata) In Washington State, Emma Houghton
Ticks On Lizards: Parasite-Host Interactions Of The Southern Alligator Lizard (Elgaria Multicarinata) In Washington State, Emma Houghton
Undergraduate Honors Theses
I investigated interactions between ectoparasites (ticks) and their host, the southern alligator lizard (Elgaria multicarinata). Alligator lizards are capable of complement-mediated killing of the Lyme disease spirochete carried by ticks and may potentially reduce Lyme disease prevalence by cleansing pathogenic organisms from ticks. Despite this, little is known about host-parasite dynamics in alligator lizards. My goals were to 1) assess patterns of tick presence (i.e. parasite load) on alligator lizards and 2) investigate potential negative effects of ticks on alligator lizards. I sampled lizards during the summer of 2019 near Catherine Creek, along the Columbia River Gorge in southern Washington. …
Toll Like Receptor 4 Stimulation Increases Scavenger Receptor A Expression On Murine Macrophages, Mackenzie L. Guthrie
Toll Like Receptor 4 Stimulation Increases Scavenger Receptor A Expression On Murine Macrophages, Mackenzie L. Guthrie
Undergraduate Honors Theses
Sepsis is the body’s response to an overwhelming infection and is a serious consequence of critical illness. It can cause tissue damage, organ failure, and death. Sepsis continues to have an unacceptably high mortality rate, due to the lack of effective treatments. Specific therapeutic targets for sepsis remain elusive since the complex functional changes that result in a septic state remain poorly understood. Macrophage Scavenger Receptor A (SRA, CD204) is a surface receptor that binds negatively charged, endogenous and exogenous ligands. We have discovered that SRA plays a significant role in the pathophysiology of sepsis. We have shown that mice …
Demography And Disease Of The Rare Shrub Buckleya Distichophylla (Santalaceae) In Northeastern Tennessee, William Seth Ratliff
Demography And Disease Of The Rare Shrub Buckleya Distichophylla (Santalaceae) In Northeastern Tennessee, William Seth Ratliff
Undergraduate Honors Theses
Piratebush (Buckleya distichophylla (Nutt.) Torr.) is a rare, hemiparasitic shrub with the only extant populations in western North Carolina, northeastern Tennessee, and southwestern Virginia. The preferred natural hosts of piratebush, Carolina and eastern hemlocks, have seen sharp declines over the last decade due to the invasive hemlock woolly adelgid. Virginia pine, another important host of piratebush, is also susceptible to disease, specifically Cronartium appalachianum, a rust fungus for which piratebush is the secondary host. This study described and analyzed current demographic parameters of three Tennessee piratebush populations. Additionally, spatial patterns of disease and demographic characters were analyzed. These …