Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- Alleles (1)
- Biology (1)
- Biology and life sciences (1)
- Blood pressure (1)
- Body mass index (1)
-
- Calcitriol (1)
- Cholesterol (1)
- Cohort studies (1)
- Computational biology (1)
- Computer and information sciences (1)
- Finland (1)
- Gene regulatory networks (1)
- Genetic (1)
- Genetics (1)
- Glycosylated (1)
- Great britain (1)
- Hdl (1)
- Hemoglobin a (1)
- Humans (1)
- Ldl (1)
- Likelihood functions (1)
- Mode (1)
- Models (1)
- Network analysis (1)
- Polymorphism (1)
- Qh301-705.5 (1)
- Receptors (1)
- Regulatory networks (1)
- Research article (1)
- Retinoid x receptors (1)
Articles 1 - 2 of 2
Full-Text Articles in Biology
Phenotypic Robustness And The Assortativity Signature Of Human Transcription Factor Networks, Dov A. Pechenick, Joshua L. Payne, Jason H. Moore
Phenotypic Robustness And The Assortativity Signature Of Human Transcription Factor Networks, Dov A. Pechenick, Joshua L. Payne, Jason H. Moore
Dartmouth Scholarship
Many developmental, physiological, and behavioral processes depend on the precise expression of genes in space and time. Such spatiotemporal gene expression phenotypes arise from the binding of sequence-specific transcription factors (TFs) to DNA, and from the regulation of nearby genes that such binding causes. These nearby genes may themselves encode TFs, giving rise to a transcription factor network (TFN), wherein nodes represent TFs and directed edges denote regulatory interactions between TFs. Computational studies have linked several topological properties of TFNs - such as their degree distribution - with the robustness of a TFN's gene expression phenotype to genetic and environmental …
Interaction Between Allelic Variations In Vitamin D Receptor And Retinoid X Receptor Genes On Metabolic Traits, Karani S. Vimaleswaran, Alana Cavadino, Diane J. Berry, Massimo Mangino, Peter Andrews, Jason H. Moore
Interaction Between Allelic Variations In Vitamin D Receptor And Retinoid X Receptor Genes On Metabolic Traits, Karani S. Vimaleswaran, Alana Cavadino, Diane J. Berry, Massimo Mangino, Peter Andrews, Jason H. Moore
Dartmouth Scholarship
Low vitamin D status has been shown to be a risk factor for several metabolic traits such as obesity, diabetes and cardiovascular disease. The biological actions of 1, 25-dihydroxyvitamin D, are mediated through the vitamin D receptor (VDR), which heterodimerizes with retinoid X receptor, gamma (RXRG). Hence, we examined the potential interactions between the tagging polymorphisms in the VDR (22 tag SNPs) and RXRG (23 tag SNPs) genes on metabolic outcomes such as body mass index, waist circumference, waist-hip ratio (WHR), high- and low-density lipoprotein (LDL) cholesterols, serum triglycerides, systolic and diastolic blood pressures and glycated haemoglobin in the 1958 …