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Articles 1 - 5 of 5
Full-Text Articles in Biology
Mir125a As Molecular Target Of Vitamin D Mediated Inhibition Of Cd4+ T Cell Differentiation Into Th17 Cells In Mrl/Lpr Lupus-Prone Mice, Miranda Hilt
Undergraduate Distinction Papers
The dynamic function of vitamin D in an array of immunomodulatory and anti-inflammatory mechanisms and its implication in the pathogenesis of autoimmune diseases has been the topic of much recent scholarship. Here I attempt to elucidate the molecular mechanism of vitamin D-mediated inhibition of the differentiation of CD4+ T cells into pro-inflammatory Th17 cells in MRL/lpr lupus prone mice by investigating how miR-125a expression is affected by dietary modulation of cholecalciferol (vitamin D3). MRL/MpJ and MRL/lpr mice were split into three experimental groups and fed specially formulated diets that varied in their concentrations of vitamin D. …
Effects Of Temperature And Plant And Animal Diets On Metabolic Rate In The Juvenile Red Eared Slider (Trachemys Scripta Elegans), Taylor Macdonald, Sarah Bouchard
Effects Of Temperature And Plant And Animal Diets On Metabolic Rate In The Juvenile Red Eared Slider (Trachemys Scripta Elegans), Taylor Macdonald, Sarah Bouchard
Undergraduate Honors Thesis Projects
Specific dynamic action (SDA) is the energy expended during ingestion, digestion, absorption, and assimilation of a meal, and is influenced by meal (type, size, composition, and temperature) and environmental temperature. Understanding the effect of meal type and environmental temperature on SDA in turtles is important in describing how T. s. elegans may acclimate with changing environmental temperatures. In this study, we conducted feeding trials in which we fed juvenile T. s. elegans duckweed and mealworm diets at 25°C and 30°C. We measured the rate of oxygen consumption as a proxy for metabolic rate after feeding for four 30 minute consecutive …
Ohio Anuran Gut Microbiomes, Serena Hoffman
Ohio Anuran Gut Microbiomes, Serena Hoffman
Undergraduate Honors Thesis Projects
Recent studies focusing on the skin and gut microbiome of vertebrates have found how important microbiomes are to maintaining host health. Understanding the role the gut microbiome plays to host health is of great importance for conservation. Less is known about the gut microbiome than the skin microbiome for amphibians. Literature is especially lacking for local Ohio anuran species. The purpose of this study was to establish the baseline composition of the gut microbiome for local Ohio anurans and to determine whether host species or habitat is the best predictor of gut microbiome composition. Tadpoles were collected from seven different …
Antimicrobial Properties Of An Unknown Microorganism Isolated From The Local Environment, Danielle Duryea
Antimicrobial Properties Of An Unknown Microorganism Isolated From The Local Environment, Danielle Duryea
Undergraduate Honors Thesis Projects
Bacterial species that cause disease can usually be combatted with antibiotics; but as the years pass, more and more bacterial pathogens are becoming resistant to these treatments. In fact, the Center for Disease Control has identified eighteen classes of bacteria ranging from urgent to concerning threats due antibiotic resistance (2019), warning the advance of an antibiotic resistance crisis in which untreatable bacterial infections will become a leading cause of death (Bennadi, 2014). The Small World Initiative is a program created in 2012 at Yale University to address the antibiotic crisis through a crowdsourcing effort where undergraduate students are encouraged to …
A Reexamination Of The Freshwater Mussel Community Of The Little Miami River, Emily Davis
A Reexamination Of The Freshwater Mussel Community Of The Little Miami River, Emily Davis
Undergraduate Honors Thesis Projects
Understanding the changes in biodiversity and local freshwater mussel populations is critical to mitigate the risks to these populations. Freshwater ecosystems continue to degrade rapidly. The freshwater mussel community of the Little Miami River is degraded and has been in decline for many years. The biodiversity contained within freshwater ecosystems is lost at unprecedented rates influenced by human activity. Freshwater mussels play a key role in understanding the effects of human activity on freshwater ecosystems as well as maintaining the health of freshwater habitats. However, they are also sensitive to changes and disturbances, in their ecosystems. This study involved monitoring …