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Somatostatin Regulates Raw 264.7 Cell Cytokine Release, Shilpa Swarup
Somatostatin Regulates Raw 264.7 Cell Cytokine Release, Shilpa Swarup
Seton Hall University Dissertations and Theses (ETDs)
Immigrant monocytes and resident macrophages propagate the vertebrate innate immune response through cell migration and cytokine production. Monocytes responding to inflammatory challenge migrate into tissues, and as resident macrophages, release a major pro-inflammatory cytokine, tumor necrosis factor a (TNF-a). Macrophge cytokine synthesis is known to be under both negative and positive regulatory control. Recent studies have shown that somatostatin (SRIF) regulates monocyte and peritoneal macrophages. However, the effects of SRIF on RAW 264.7 cells, a transformed monocyte/macrophage cell line, have not been investigated. In the present study, SRIF effect on cytokine release in LPS stimulated RAW 264. 7 cells was …