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Jak3/Stat5 Signaling Cascade Represents A Therapeutic Target To Treat Select Hematologic Malignancies, Damaris Rosado
Jak3/Stat5 Signaling Cascade Represents A Therapeutic Target To Treat Select Hematologic Malignancies, Damaris Rosado
Open Access Theses & Dissertations
Tyrosine kinases are an essential component of cell signal transduction pathways, many of which promote cellular proliferation. However, when a tyrosine kinase is aberrantly activated or its negative regulation is lost, the result can be malignancy. In humans, 90 tyrosine kinases are present and of these, 51 have been linked to a malignancy through mutation or overexpression. Janus kinase 3 (JAK3) is one such kinase that upon hyperactivation, due to a somatic mutation, has been linked to cancer including its substrate, signal transducer and activator of transcription (STAT5). Few studies have investigated the role of JAK3/STAT5 pathways in hematopoietic cancers …
Systematics Of Leptopelis (Anura: Arthroleptidae) From The Itombwe Plateau, Eastern Democratic Republic Of The Congo, Francisco Portillo
Systematics Of Leptopelis (Anura: Arthroleptidae) From The Itombwe Plateau, Eastern Democratic Republic Of The Congo, Francisco Portillo
Open Access Theses & Dissertations
Leptopelis, a genus of Central African treefrogs, includes 51 species that live in tropical forests and savannas. Currently, only two species of Leptopelis are known from the poorly explored Itombwe Plateau in eastern Democratic Republic of the Congo (DRC). Itombwe is renowned among conservationists for its rich and endemic amphibian fauna, including: Xenopus itombwensis, Chrysobatrachus cupreonitens, Laurentophryne parkeri, Hyperolius leleupi and at least three species of Arthroleptis. Evolutionary relationships of Itombwe Leptopelis were examined by sequencing two mitochondrial genes (16S: 557 bp [base pairs], cyt b: 620 bp) and one nuclear gene (RAG1: 761 bp). Results recovered strong support for …