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Full-Text Articles in Biology
Acute Sleep Fragmentation Induces Tissue-Specific Changes In Cytokine Gene Expression And Increases Serum Corticosterone Concentration, Jennifer Dumaine
Acute Sleep Fragmentation Induces Tissue-Specific Changes In Cytokine Gene Expression And Increases Serum Corticosterone Concentration, Jennifer Dumaine
Masters Theses & Specialist Projects
Sleep fragmentation induces acute inflammation and increases glucocorticosteroids in vertebrates. Obesity and sleep fragmentation are often concurrent pro-inflammatory conditions in patients with obstructive sleep apnea. Despite the association between the two, their simultaneous effects on immune and endocrine profiles have not been explored. In the first experiment, we investigated changes in proinflammatory (IL-1β, TNF-α) and anti-inflammatory (TGF-β1) cytokine gene expression in the periphery (liver, spleen, fat, and heart) and brain (hypothalamus, prefrontal cortex, and hippocampus) in mice exposed to various intervals of sleep fragmentation. Serum corticosterone concentration was also assessed. Sleep was disrupted in male C57BL/6J mice using an automated …
Ogden College Of Science & Engineering Newsletter (Winter 2013), Cheryl Stevens, Dean
Ogden College Of Science & Engineering Newsletter (Winter 2013), Cheryl Stevens, Dean
Ogden College of Science & Engineering Publications
No abstract provided.
Biomass Assisted Synthesis Of Antibacterial Gold Nanoparticles And Commentary On Its Future Potential And Applications In Medicine, Chad Willis
Mahurin Honors College Capstone Experience/Thesis Projects
Xylose is a natural monosaccharide found in biomass such as straw, pecan shells, cottonseed hulls, and corncobs. Using this monosaccharide, we report the green synthesis and characterization of biocompatible, biodegradable xylose encapsulated gold nanoparticles (Xyl-GNPs) with potential antibacterial activity. GNPs were synthesized using the bioreduction property of xylose on the chloroaurate anions in an aqueous solution at room temperature and at atmospheric pressure. The characterization of synthesized GNPs was examined by UV-vis spectroscopy; transmission electron microscopy (TEM), energy-dispersive x-ray spectroscopy (EDS) and fourier transform infrared spectroscopy (FTIR). Results indicate that the particles were stable; near spherical in shape with an …
A Method Based On Conserved Multiple Amino Acid Properties To Predict Amino Acid Substitutions Which Maintain The Protein Structure, Avinash M. Baktula
A Method Based On Conserved Multiple Amino Acid Properties To Predict Amino Acid Substitutions Which Maintain The Protein Structure, Avinash M. Baktula
Masters Theses & Specialist Projects
A METHOD BASED ON CONSERVED MULTIPLE AMINO ACID PROPERTIES TO PREDICT AMINO ACID SUBSTITUTIONS WHICH MAINTAIN THE PROTEIN STRUCTURE Avinash M. Baktula September 16, 2004 1-117 Directed by: Claire A. Rinehart, Doug McElroy and Sigrid Jacobshagen Department of Biology Western Kentucky University Proteins often contain several domains, each with a distinct structure. Such domains have evolved as units that, when combined in various arrangements, produce proteins of unique structure. This study was conducted to identify amino acid substitutions that don’t change structure. Amino acid properties which were conserved in proteins with identical structures were used to predict a set of …