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Biology

Theses/Dissertations

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Full-Text Articles in Bioinformatics

The Role Of Machine Learning And Network Analyses In Understanding Microbial Composition In An Experimental Prairie, Ali Eastman Oku Jan 2023

The Role Of Machine Learning And Network Analyses In Understanding Microbial Composition In An Experimental Prairie, Ali Eastman Oku

Graduate Research Theses & Dissertations

Machine learning and network analyses are powerful modern tools can process and map out connections between large amount of ecological data from complex environmental communities. Random forests, an ensemble machine learning algorithm, are particularly powerful as they can capture complex patterns in data while remaining easily interpretable. These tools are specifically useful in experimental settings where different types of data are collected. The aim of this study was to demonstrate the utility of machine learning models and network analyses at analyzing diverse ecological data from dynamic plant-soil microbial communities in a prairie ecosystem. Our experimental system is an experimental prairie …

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Construction And Analysis Of Three Multi-Partite Synthetic Microbial Communities, Alexander J. Lazzara, Jacob K. Fanning May 2021

Construction And Analysis Of Three Multi-Partite Synthetic Microbial Communities, Alexander J. Lazzara, Jacob K. Fanning

Honors Theses

Microbial Communities are of interest to molecular biologists hoping to understand the nature of metabolic interactions between co-existing, or possibly mutualistic, organisms. These interactions are ubiquitous in nature, but understanding the molecular mechanisms involved remains challenging and not well understood. Here, we design three tri-partite microbial circuits based on possible interactions among involved microbes, which are discussed and may suggest mutualistic interactions. Carbon and nitrogen molecular pathways and the intracellular metabolism of each microbe is discussed. We present minimal growth media that will ensure that organisms utilize available resources, which may originate from metabolic processes in neighboring microbes, simulating a …

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The Role Of Software Engineering In Bioinformatics, Brendan Sean Lawlor Jan 2021

The Role Of Software Engineering In Bioinformatics, Brendan Sean Lawlor

Theses

This thesis proposes that by applying state-of-the-art software engineering tools, techniques and frameworks to currently recognised challenges in bioinformatics, improved outcomes can be attained in that field. It begins by decomposing software engineering into two categories, namely process and architecture, and choosing two key challenges in the practice of bioinformatics: reproducibility and scalability. The body of the thesis is an exploration of the intersection between these two software engineering categories and these two bioinformatics challenges. The question is asked: Can best practices in professional software engineering be applied to address key issues in the bioinformatics domain, creating positive outcomes? And …

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Composition And Homology In The Taxonomic Classification Of Escherichia Coli, Tanya Irani Jan 2021

Composition And Homology In The Taxonomic Classification Of Escherichia Coli, Tanya Irani

Theses and Dissertations (Comprehensive)

As new techniques have been introduced, specifically the possibility of complete genome sequencing, better methods of defining bacterial species have also been proposed. One of the most recently proposed methods, using bioinformatic techniques, is to calculate the average nucleotide identity (ANI) between the homologous genome segments of different isolates. Another method for species discrimination that has been tested successfully is the similarity of DNA compositional signatures. However, in a recent update, DNA signatures split the available Escherichia coli complete genomes into three groups. To check if this result was consistent with such genomes belonging to different species, we tested methods …

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A Genomic Analysis Of Bobcat Populations In North America With A Comparison To The Canada Lynx: An Assessment Of Local Adaptation To Unique Ecoregions And Phylogeography, Jennifer C. Broderick May 2020

A Genomic Analysis Of Bobcat Populations In North America With A Comparison To The Canada Lynx: An Assessment Of Local Adaptation To Unique Ecoregions And Phylogeography, Jennifer C. Broderick

Electronic Theses and Dissertations

Bobcats (Lynx rufus) are an ecologically and genetically diverse species with a large contiguous range throughout North America. The species not only has a wide array of phenotypic variation compared to other mammals, but shows marked adaptability across ecozones with differing ecological influences. It is these various selective pressures in distinctive parts of the continent that have likely led to localized adaptations within the bobcat metapopulations. The species is also marked by its ability to maintain connectivity and populations in anthropogenically developed areas, an advantage it has over other felids, including its close relative the Canada lynx ( …

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Newall Glacier Nucleic Acid Analysis, Shannon Turner Apr 2018

Newall Glacier Nucleic Acid Analysis, Shannon Turner

Honors Projects

The Newall Glacier is located in Antarctica between Mount Newall and Mount Weyant, at approximately 77°30′S, 162°50′E. Having existed for millions of years, and being rarely touched by human populations, glaciers are a major source of information on climate and life in the past. During the past 5 decades, a multi-country team of scientists have collaborated to drill into many of Antarctica’s glaciers and ice fields, removing ice cores for scientific investigation. The ice core section chosen for this project was drilled from the Newall Glacier in 1988 and its depth was from 100.670 to 101.000 m. The purpose of …

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