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Full-Text Articles in Bioinformatics
Mapping The Human Vasculature By In Vivo Phage Display, Julianna Bronk
Mapping The Human Vasculature By In Vivo Phage Display, Julianna Bronk
Dissertations & Theses (Open Access)
In vivo phage display screenings by intravenous injection of a random phage-displayed peptide library allow for the selection of peptides that localize to specific vascular beds. At the University of Texas MD Anderson Cancer Center, we have had the opportunity to perform phage display screenings in cancer patients in order to select for cancer specific targets directly in humans. These targets serve to define biochemical diversity of endothelial cell surfaces and can be validated and explored towards the design of vascular-targeted pharmacology. In the most recent patient screen, samples were recovered from hepatocellular carcinoma (HCC) as well as 26 additional …
Node-Oriented Workflow (Now): A Command Template Workflow Management Tool For High Throughput Data Analysis Pipelines, Eric B. Lipsky, Brian R. King, Gerard Tromp
Node-Oriented Workflow (Now): A Command Template Workflow Management Tool For High Throughput Data Analysis Pipelines, Eric B. Lipsky, Brian R. King, Gerard Tromp
Faculty Journal Articles
Next generation sequencing (NGS) systems produce vast quantities of data that require substantial computational resources for typical analysis tasks. In addition, data that are generated by different NGS systems are not homogeneous. Moreover, there are an overwhelming number of tools available for performing typical tasks. Managing NGS workflows involves writing custom scripts that quickly grow in complexity, often resulting in unwieldy workflows that underutilize typical high performance compute resources, and increase the demands of the staff managing these workflows. We present Node-Oriented Workflow (NOW), a dynamic command template workflow engine for high performance distributed computing (HPC) systems. Our system provides …