Bioinformatics Commons^™

An Svd-Based Comparison Of Nine Whole Eukaryotic Genomes Supports A Coelomate Rather Than Ecdysozoan Lineage, Gary W. Stuart, Michael W. Berry

Faculty Publications and Other Works -- General Biology

Background

Eukaryotic whole genome sequences are accumulating at an impressive rate. Effective methods for comparing multiple whole eukaryotic genomes on a large scale are needed. Most attempted solutions involve the production of large scale alignments, and many of these require a high stringency pre-screen for putative orthologs in order to reduce the effective size of the dataset and provide a reasonably high but unknown fraction of correctly aligned homologous sites for comparison. As an alternative, highly efficient methods that do not require the pre-alignment of operationally defined orthologs are also being explored.

Results

A non-alignment method based on the Singular …