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Bioinformatics Commons

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2017

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Articles 1 - 7 of 7

Full-Text Articles in Bioinformatics

Using Data To Improve Services For Infants With Hearing Loss: Linking Newborn Hearing Screening Records With Early Intervention Records, Maria Gonzalez, Lori Iarossi, Yan Wu, Ying Huang, Kirsten Siegenthaler Nov 2017

Using Data To Improve Services For Infants With Hearing Loss: Linking Newborn Hearing Screening Records With Early Intervention Records, Maria Gonzalez, Lori Iarossi, Yan Wu, Ying Huang, Kirsten Siegenthaler

Journal of Early Hearing Detection and Intervention

The purpose of this study was to match records of infants with permanent hearing loss from the New York Early Hearing Detection and Intervention Information System (NYEHDI-IS) to records of infants with permanent hearing loss receiving early intervention services from the New York State Early Intervention Program (NYSEIP) to identify areas in the state where hearing screening, diagnostic evaluations and referrals to the NYSEIP were not being made or documented in a timely manner. Data from 2014-2016 NYEHDI-IS and NYEIS information systems were matched using The Link King. There were 274 infants documented in NYEIS Information System as receiving early …


Big Data: Computational Biology Opens A New Window On The World's Challenges For Colby Scientists, Kate Carlisle Oct 2017

Big Data: Computational Biology Opens A New Window On The World's Challenges For Colby Scientists, Kate Carlisle

Colby Magazine

"What makes us 'us' and not a plant? Not a bacteria, or a virus," asks Andrea Tilden, the J. Warren Merrill Associate Professor of Biology and a genomics expert. "Any one genome has six thousand novels worth of information. Computational biology is the tool we use to read them."


Processing Conservation Indicators With Open Source Tools: Lessons Learned From The Digital Observatory For Protected Areas, Lucy Bastin, Andrea Mandrici, Luca Battistella, Grégoire Dubois Sep 2017

Processing Conservation Indicators With Open Source Tools: Lessons Learned From The Digital Observatory For Protected Areas, Lucy Bastin, Andrea Mandrici, Luca Battistella, Grégoire Dubois

Free and Open Source Software for Geospatial (FOSS4G) Conference Proceedings

The European Commission has a commitment to open data and the support of open source software and standards. We present lessons learnt while populating and supporting the web and map services that underly the Joint Research Centre's Digital Observatory for Protected Areas. Challenges include: large datasets with highly complex geometries; topological inconsistencies, compounded by reprojection for equal-area calculations; multiple different representations of the same geographical entities, for example coastlines; licensing requirement to continuously update indicators to respond to monthly changes in the authoritative data. In order to compute and publish an array of indicators, we used a range of open …


Modelling The Future Spread Of Native And Alien Congeneric Species In Subterranean Habitats — The Case Of Meta Cave-Dwelling Spiders In Great Britain, Stefano Mammola Aug 2017

Modelling The Future Spread Of Native And Alien Congeneric Species In Subterranean Habitats — The Case Of Meta Cave-Dwelling Spiders In Great Britain, Stefano Mammola

International Journal of Speleology

The threshold zones between the epigean and hypogean environments are generally characterized by less harsh ecological conditions than deep subterranean habitats, and usually support a greater abundance of organisms. Transitional habitats such as these should be more easily colonised by alien species, especially by those possessing exaptations suitable for subterranean life. In spite of this, few studies have been conducted to unravel the ecological dynamics between native and alien species in the habitats situated at the epigean/hypogean interface. A unique test case is offered by cave-dwelling Meta orb-weaver spiders in Great Britain (Araneae: Tetragnathidae). One species, M. menardi, is …


Genome-Wide Association Study Of Prolactin In Cerebrospinal Fluid And Plasma, Lorna Sheradyn Hamilton, Dr. John Kauwe Jun 2017

Genome-Wide Association Study Of Prolactin In Cerebrospinal Fluid And Plasma, Lorna Sheradyn Hamilton, Dr. John Kauwe

Journal of Undergraduate Research

Prolactin is the major hormone involved in milk lactation for pregnant women and has been discovered to play a role in a variety of biological functions. Several other functions include the immune system, reproductive system, maternal behavior, insulin production, and stimulating neurogenesis.1 2 Using prolactin levels from both cerebrospinal fluid and blood plasma from nearly 500 individuals, we will be able to conduct a genome-wide association study to identify single-nucleotide polymorphisms (SNPs), which will lead to a better understanding of what genes are playing a significant role in prolactin’s production and regulation.


Exploring The Use Of Free Bioinformatics Modules In An Introductory Biochemistry Course, Charlsey Dodgen, Uzezi Uwerosuo, Chulhee Kang, Cathy Lee Mar 2017

Exploring The Use Of Free Bioinformatics Modules In An Introductory Biochemistry Course, Charlsey Dodgen, Uzezi Uwerosuo, Chulhee Kang, Cathy Lee

Georgia Journal of Science

Although bioinformatics, the use of computational science to study biology, has become imperative in many areas of the biological sciences and related career paths, introductory biochemistry courses may disregard practical knowledge on bioinformatics. For this reason, we merged a hands-on activity module into an undergraduate biochemistry course in two ways. First, we incorporated bioinformatics modules for building phylogenetic trees by aligning the active sites of 10 chosen related α-amylase enzymes using freely available data. Secondly, we chose three of those 10 α-amylase enzymes to compare the 3D structure of their active sites. This module gives the students an opportunity to …


Phylogeography And Vicariant Separation Of Two River Darters, Percina Uranidea And Percina Vigil, From Rivers That Drain The North American Interior Highlands, T. Yamashita, J. M. Rigsby, J. Stoeckel Jan 2017

Phylogeography And Vicariant Separation Of Two River Darters, Percina Uranidea And Percina Vigil, From Rivers That Drain The North American Interior Highlands, T. Yamashita, J. M. Rigsby, J. Stoeckel

Journal of the Arkansas Academy of Science

The phylogeography and separation of two river darters, Percina uranidea and P. vigil were investigated through sequencing of the mitochondrial Cytochrome B and Cytochrome Oxidase genes. These molecular markers revealed the darters exhibit moderate genetic divergence between two large river drainage systems within the Mississippi River basin associated with the Interior Highlands of midwestern North America. An additional haplotype network analysis also supported these trends. Phylogenetic divergence dating indicated that population separation between the river systems occurred after recent Pleistocene glacial events rather than an early Pleistocene separation.