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Discordant Classification Of Transposable Elements In Segmental Duplications Raise Concerns About Subfamily Definitions, Gilia R. Patterson
Discordant Classification Of Transposable Elements In Segmental Duplications Raise Concerns About Subfamily Definitions, Gilia R. Patterson
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Most of the human genome comes from transposable elements (TEs), sequences of DNA that can move and insert copies of themselves throughout the genome. TE sequences both inform and complicate analyses of genomes, so it is important that TEs are annotated completely and accurately. Remnants of TEs are annotated and classified into subfamilies based on their DNA sequences. A subfamily represents all the copies generated in a burst of replication by a few closely related TEs. Wacholder et al. (2014) suggested that the current methods for representing subfamilies are not accurate and should be reevaluated. We expand on this discussion …