Biochemistry, Biophysics, and Structural Biology Commons^™

Inhibition Of Matrix Metalloproteinase-9 Secretion By Dimethyl Sulfoxide And Cyclic Adenosine Monophosphate In Human Monocytes, Darcy Denner, Maria Udan-Johns, Michael Nichols

Chemistry & Biochemistry Faculty Works

BACKGROUND Matrix metalloproteinases (MMPs), including MMP-9, are an integral part of the immune response and are upregulated in response to a variety of stimuli. New details continue to emerge concerning the mechanistic and regulatory pathways that mediate MMP-9 secretion. There is significant evidence for regulation of inflammation by dimethyl sulfoxide (DMSO) and 3',5'-cyclic adenosine monophosphate (cAMP), thus investigation of how these two molecules may regulate both MMP-9 and tumor necrosis factor α (TNFα) secretion by human monocytes was of high interest. The hypothesis tested in this study was that DMSO and cAMP regulate MMP-9 and TNFα secretion by distinct mechanisms. …