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Full-Text Articles in Biochemistry, Biophysics, and Structural Biology
Specialized Metabolism In Retina, Retinal Pigmented Epithelium, And Testis, Siyan Zhu
Specialized Metabolism In Retina, Retinal Pigmented Epithelium, And Testis, Siyan Zhu
Graduate Theses, Dissertations, and Problem Reports
The retina and its neighboring retinal pigmented epithelium (RPE) are high energy-demanding and metabolically active tissues with specialized and complementary metabolism. They are metabolically interdependent and impact each other’s viability. Interestingly, many of the metabolic features in the retina and RPE are shared with the testis. For example, testis is also energy costly due to continuous sperm differentiation and it has similar metabolic inter-dependence between different testis cells. Both the retina and testis are vulnerable to mitochondrial metabolic impairments.
We conducted three research projects to understand 1) the nutrient utilization and communication in retina and RPE; 2) The profiling of …
The Musashi Rna Binding Proteins Are Regulators Of Alternative Splicing And Protein Expression In Photoreceptor Cells, Fatimah Kh. Matalkah
The Musashi Rna Binding Proteins Are Regulators Of Alternative Splicing And Protein Expression In Photoreceptor Cells, Fatimah Kh. Matalkah
Graduate Theses, Dissertations, and Problem Reports
The Musashi (Msi) family of RNA binding proteins consists of two paralogs, Msi1 and Msi2, that are highly conserved across species. The two paralogs have emerged as factors that promote stem cell proliferation by post-transcriptionally regulating translation. In addition to their expression in stem cells, the Musashi proteins are also expressed in postmitotic neurons, including the photoreceptor cells. The Musashi proteins have been observed to maintain high expression levels in the postmitotic photoreceptors within the eye of both invertebrates and vertebrates. These observations suggest an additional role in the maintenance of terminally differentiated neurons.
Building upon these observations, we investigated …