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The Musashi Rna Binding Proteins Are Regulators Of Alternative Splicing And Protein Expression In Photoreceptor Cells, Fatimah Kh. Matalkah
The Musashi Rna Binding Proteins Are Regulators Of Alternative Splicing And Protein Expression In Photoreceptor Cells, Fatimah Kh. Matalkah
Graduate Theses, Dissertations, and Problem Reports
The Musashi (Msi) family of RNA binding proteins consists of two paralogs, Msi1 and Msi2, that are highly conserved across species. The two paralogs have emerged as factors that promote stem cell proliferation by post-transcriptionally regulating translation. In addition to their expression in stem cells, the Musashi proteins are also expressed in postmitotic neurons, including the photoreceptor cells. The Musashi proteins have been observed to maintain high expression levels in the postmitotic photoreceptors within the eye of both invertebrates and vertebrates. These observations suggest an additional role in the maintenance of terminally differentiated neurons.
Building upon these observations, we investigated …