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Full-Text Articles in Biochemistry, Biophysics, and Structural Biology
Mitochondrial Roles In Developmentally Programmed Heart Disease, Eli John Louwagie
Mitochondrial Roles In Developmentally Programmed Heart Disease, Eli John Louwagie
Dissertations and Theses
Offspring of diabetic and obese mothers (ODOM) have greater risks of heart disease at birth and later in life. However, prevention is hindered because underlying mechanisms are poorly understood. Mounting studies in the Developmental Origins of Health and Disease field suggest that mitochondria play key roles in developmentally programmed heart disease similar to the roles they play in cardiomyopathy in adults with diabetes and obesity. However, whether mitochondria are responsible for the short[1]and long-term cardiac disease seen in ODOM remains unknown. Here, we sought to delineate the roles of mitochondria in the hearts of ODOM, determine whether mitochondria are playing …
The Physiology And Biochemistry Of Isolated Skeletal Muscle Mitochondria : A Comparative Study, Mark Lowell Wagner
The Physiology And Biochemistry Of Isolated Skeletal Muscle Mitochondria : A Comparative Study, Mark Lowell Wagner
Dissertations and Theses
The physiological limit to maximum aerobic capacity (VO2max) in vertebrates has been attributed to cardiovascular oxygen delivery, to the ability of the muscle cells to consume oxygen, or to a fine-tuned development of all components of the respiratory system such that no single component can be shown to limit VO2max. The above hypotheses have each been developed using different experiments with different animals. The comparative studies uniting these animals and methods are limited. In order to further our knowledge of the cellular limit to VO2max, skeletal muscle mitochondria were isolated from species representing four …