Biochemistry, Biophysics, and Structural Biology Commons^™

Antifungal Activity Of Substituted 8-Quinolinol-5- And 7-Sulfonic Acids: A Mechanism Of Action Is Suggested Based On Intramolecular Synergism / Hermon Gershon, Muriel Gershon, & Donald D. Clarke Harding Laboratory, The New York Botanical Garden, Bronx, New York 10458, Usa; Department Of Chemistry, Fordham University, Bronx, New York 10458, Usa, Herman Gershon, Muriel Gershon, Donald Dudley Clarke Phd

Chemistry Faculty Publications

8-Quinolinol-5-sulfonic acid was nearly devoid of antimicrobial activity, due to what was believed to be an unfavorable partition coefficient. Since twenty six 8-quinolinol-5- and 7 -sulfonic acids were available from our previous work, they were tested against six fungi. The 7 -chloro and 7 -bromo-5-sulfonic acids and the 5-chloro and 5-bromo-7 -sulfonic acids showed fungal inhibition within one order of magnitude of that of 8-quinolinol. It is suggested that a nonchelating mechanism is in part responsible for this fungitoxicity. Five additional 5-sulfonic acids with chlorine in positions 3-, 6-, 3,6-, 3,7-, and 6,7- that were suitable for studies in synergism …