Open Access. Powered by Scholars. Published by Universities.®
Biochemistry, Biophysics, and Structural Biology Commons™
Open Access. Powered by Scholars. Published by Universities.®
- Institution
- Keyword
-
- 1 H NMR (1)
- 13C NMR (1)
- 5-Iodo-2-methyl-8-quinolinol (1)
- 5-Iodo-8-quinolinol (1)
- 7-Iodo-2-methyl-8-quinolinol (1)
-
- 7-Iodo-8-quinolinol (1)
- Bis(2-methyl-7-nitro-8-quinolinolato)copper(II) (1)
- Bis(2-methyl-8-quinolinolato)copper( II) (1)
- Bis(7-fluoro-8-quinolinolato) copper(II) (1)
- Bis(8-quinolinolato)copper(II) complexes (1)
- Crystal structures (1)
- DNA replication/DNA polymerase/accessory proteins/DNA primase (1)
- LPA production; ovarian cancer cells; PMA; PKC; PLA2 (1)
- UV spectra (1)
Articles 1 - 4 of 4
Full-Text Articles in Biochemistry, Biophysics, and Structural Biology
Phorbol 12-Myristate 13-Acetate Stimulates Lysophosphatidic Acid Secretion From Ovarian And Cervical Cancer Cells But Not From Breast Or Leukemia Cells, Zhongzhou Shen, Jerome Belinson, Richard E. Morton, Yan Xu
Phorbol 12-Myristate 13-Acetate Stimulates Lysophosphatidic Acid Secretion From Ovarian And Cervical Cancer Cells But Not From Breast Or Leukemia Cells, Zhongzhou Shen, Jerome Belinson, Richard E. Morton, Yan Xu
Chemistry Faculty Publications
Lysophosphatidic acid (LPA) is present in ascites from patients with ovarian cancer. It stimulates calcium release and growth of ovarian cancer cells bothin vitroandin vivo.Recently, we found that LPA levels were significantly elevated in plasma from patients with ovarian cancer and other gynecological cancers. In contrast, LPA levels were not elevated in patients with breast cancer and leukemias. In view of this, we investigated whether gynecological cancer cells could produce LPA. LPA was extracted from the supernatant of cells culturedin vitroand purified by thin layer chromatography. After hydrolysis and transmethylation, the fatty acid derivatives were analyzed by gas chromatography. We …
Simultaneous Formation Of Functional Leading And Lagging Strand Holoenzyme Complexes On A Small, Defined Dna Substrate, Anthony J. Berdis, Stephen J. Benkovic
Simultaneous Formation Of Functional Leading And Lagging Strand Holoenzyme Complexes On A Small, Defined Dna Substrate, Anthony J. Berdis, Stephen J. Benkovic
Chemistry Faculty Publications
The biochemical characterization of leading and lagging strand DNA synthesis by bacteriophage T4 replication proteins has been addressed utilizing a small, defined primer/template. The ATP hydrolysis activity of 44/62, the clamp loading complex responsible for holoenzyme assembly, was monitored during assembly of both the leading and lagging strand holoenzyme complex. The ATPase activity of 44/62 diminishes once a functional holoenzyme is assembled on both the leading and lagging strand. The assembly of the lagging strand holoenzyme is facilitated by several factors including biotinylated streptavidin blocks at the end of the fork strands, preassembly of the leading strand holoenzyme, and by …
Crystal Structures Of Copper(Ii) Complexes Of Some 2-Methyl-8-Quinolinols And Implications For Their Antifungal Activity / Massud Shoja, Herman Gershon, Diana Bray, And Donald D. Clarke Department Of Chemistry, Fordham University, Bronx, Ny 10458, Usa New York Botanical Garden, Bronx, Ny 10458, Usa, Massud Shoja Phd, Herman Gershon, Diana Bray, Donald Dudley Clarke Phd
Crystal Structures Of Copper(Ii) Complexes Of Some 2-Methyl-8-Quinolinols And Implications For Their Antifungal Activity / Massud Shoja, Herman Gershon, Diana Bray, And Donald D. Clarke Department Of Chemistry, Fordham University, Bronx, Ny 10458, Usa New York Botanical Garden, Bronx, Ny 10458, Usa, Massud Shoja Phd, Herman Gershon, Diana Bray, Donald Dudley Clarke Phd
Chemistry Faculty Publications
A hypothesis that the geometry of a potential fungicide must be consistent with that of the pores of the fungal spore wall in order to penetrate it and be toxic has been developed. Certain bis(8-quinolinolato)copper(II) complexes seemed to contradict this. To resolve this issue, structures of bis(7-fluoro-8-quinolinolato )copper(II) (1), bis(2-methyl-8-quinolinolato )copper(II) (2), and bis(2-methyl-7-nitro-8-quinolinolato)copper(II) (3) were solved. The ligands of 1 are square planar with copper at the center of symmetry. In 2 and 3 the methyl group at C2 interacts with the other 8- quinolinol ligand, producing a significant distortion of the square planar geometry which causes a rotation …
Revision Of The Assigned Structures Of 5- And 7-Iodo-8-Quinolinols And 5- And 7-Iodo-2-Methyl-8-Quinolinols / Donald D. Clarke, Herman Gershon, Massud Shoja, And Mei-Wen Yen Department Of Chemistry, Fordham University, Bronx, Ny 10458, Usa, Donald Dudley Clarke Phd, Herman Gershon, Massud Shoja Phd, Mei-Wen Yen
Revision Of The Assigned Structures Of 5- And 7-Iodo-8-Quinolinols And 5- And 7-Iodo-2-Methyl-8-Quinolinols / Donald D. Clarke, Herman Gershon, Massud Shoja, And Mei-Wen Yen Department Of Chemistry, Fordham University, Bronx, Ny 10458, Usa, Donald Dudley Clarke Phd, Herman Gershon, Massud Shoja Phd, Mei-Wen Yen
Chemistry Faculty Publications
Revised structures are presented for 5- and 7-iodo-8-quinolinols and for 5- and 7-iodo-2-methyl-8-quinolinols based on NMR studies. UV spectroscopic characterization of the compounds was also carried out