Biochemistry, Biophysics, and Structural Biology Commons^™

Acetylation Of Synaptosomal Protein: Inhibition Of Veratridine / Soll Berl, Ramiro Nunez, Arlene D. Colon, And Donald D. Clarke Mount Sinai School Of Medicine, And Chemistry Department, Fordham University, New York, New York, U.S.A., Soll Berl, Ramiro Nunez, Arlene D. Colon, Donald Dudley Clarke Phd

Chemistry Faculty Publications

Incubation of synaptosomes with [3H]acetate results in rapid labeling of protein. Labeling is decreased in the presence of veratridine, and the effect of veratridine is blocked by tetrodotoxin. Most of the radioactivity can be removed by base or acid hydrolysis, and is probably incorporated as acetate; it is this fraction that is affected by the veratridine. The data suggest that veratridine stimulates deacetylation of synaptosomal protein. This raises the question whether acetylation-deacetylation is involved in membrane function