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Structural Analysis Of Tpr Ligand Complexes Of Stip1 Implicated In Alzheimer's Disease, Andrzej Maciejewski

Electronic Thesis and Dissertation Repository

Amyloid-beta oligomers (AbOs) induce neurological dysfunction in part through the cellular prion protein (PrP^C) resulting in deregulation of Ca²⁺ homeostasis in Alzheimer’s disease (AD). Stress inducible phosphoprotein 1 (STIP1), a cochaperone of Hsp70 and Hsp90, protects neurons from AbO-induced cell death. As well, STIP1 interacts with the Ca²⁺ sensor S100A1, which is an important biomarker upregulated in AD and regulates STIP1 and other cochaperone association with Hsp70 and Hsp90. While the molecular details of STIP1-Hsp complexes are well studied, little information is available concerning alternate STIP1 binding partners. Here, we investigated the structural details of STIP1 …