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Full-Text Articles in Biochemistry, Biophysics, and Structural Biology
Protein Folding Kinetics Analysis Using Fluorescence Spectroscopy, Dhanya Dhananjayan
Protein Folding Kinetics Analysis Using Fluorescence Spectroscopy, Dhanya Dhananjayan
USF Tampa Graduate Theses and Dissertations
The conformational changes that occur during the folding of a protein is an intensely researched area because of the impact that it has on human health and cellular functions. Protein stability is crucial in the context of protein misfolding and aggregation due to its implications on misfolding diseases such as amyloid fibril degenerative diseases (Alzheimer’s, Parkinson’s). By examining the kinetics of protein folding, we can gain valuable information about the folding mechanism and help us identify potential targets for many of the protein misfolding diseases.
In this study, we present the folding and unfolding kinetics of TEM-1 β-lactamase from Escherichia …