Biochemistry, Biophysics, and Structural Biology Commons^™

The Lipid Peroxidation Product Ekode Exacerbates Colonic Inflammation And Colon Tumorigenesis, Lei Lei, Jun Yang, Jianan Zhang, Guodong Zhang

Food Science Department Faculty Publication Series

Oxidative stress is emerging as an important contributor to the pathogenesis of colorectal cancer (CRC), however, the molecular mechanisms by which the disturbed redox balance regulates CRC development remain undefined. Using a liquid chromatography?tandem mass spectrometry-based lipidomics, we found that epoxyketooctadecenoic acid (EKODE), which is a lipid peroxidation product, was among the most dramatically increased lipid molecules in the colon of azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced CRC mice. This is, at least in part, due to increased oxidative stress in colon tumors, as assessed by analyzing gene expression of oxidative markers in AOM/DSS-induced CRC mice and human CRC patients in …