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Full-Text Articles in Biochemistry, Biophysics, and Structural Biology
Lateral Phase Separations In Binary Mixtures Of Phospholipids Having Different Charges And Different Crystalline Structures, Elizabeth Luna, Harden Mcconnell
Lateral Phase Separations In Binary Mixtures Of Phospholipids Having Different Charges And Different Crystalline Structures, Elizabeth Luna, Harden Mcconnell
Elizabeth J. Luna
Synthetic dipalmitoyl phosphatidylserine exhibits a sharp chain-melting transition temperature at 51 degrees C as judged by partitioning of the spin label 2,2,6,6-tetramethylpiperidine-1-oxyl. Phase diagrams representing lateral phase separations in binary mixtures of dipalmitoyl phosphatidylserine with dipalmitoyl phosphatidylcholine as well as with dimyristoyl phosphatidylcholine are derived from paramagnetic resonance determinations of 2,2,6,6,-tetramethylpiperidine-1-oxyl partitioning, freeze-fracture electron microscopic studies and theoretical arguments that limit the general form of acceptable phase diagrams. The reported phase diagrams are the first to describe binary mixtures in which one lipid is charged and the second lipid uncharged. These phase diagrams also are the first to include the …
Multiple Phase Equilibria In Binary Mixtures Of Phospholipids, Elizabeth Luna, Harden Mcconnell
Multiple Phase Equilibria In Binary Mixtures Of Phospholipids, Elizabeth Luna, Harden Mcconnell
Elizabeth J. Luna
Approximate phse diagrams describing lateral phase separations are given for binary mixtures of dimyristoyl phosphatidylcholine with dipalmitoyl phosphatidylcholine, distearoyl phosphatidycholine, and dipalmitoyl phosphatidylethanolamine. These diagrams are based in part on freeze-fracture electron microscopic data. These phase diagrams represent an improvement over previous studies in that both solid phses (Pbeta' and Lbeta') of the phosphatidylcholines are included. Further consideration is given to the problem of binary mixtures in which there are two Pbeta' phases that do not form a continuous range of solid solutions.