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Full-Text Articles in Biochemistry, Biophysics, and Structural Biology
Determination Of Amino Acids Involved In Specificity And Activity Of Chladub2, Trent S. Arbough, John M. Hausman, Chittaranjan Das
Determination Of Amino Acids Involved In Specificity And Activity Of Chladub2, Trent S. Arbough, John M. Hausman, Chittaranjan Das
The Summer Undergraduate Research Fellowship (SURF) Symposium
Chlamydia trachomatis is a pathogen which infects humans as a sexually transmitted disease or through ocular infection, causing ocular trachoma. Ocular trachoma is the leading cause of non-congenital blindness in developing countries. The bacteria employs the deubiquitinating enzyme ChlaDUB2 to remove ubiquitin from its inclusion membrane in order to avoid lysosomal degradation. Key amino acids involved in ubiquitin recognition and cleavage were mutated in order to probe substrate specificity and catalytic activity of ChlaDUB2. Mutants were used in fluorometry assays in order to determine how the mutations affect the ability of ChlaDUB2 to release the amino methyl coumarin (AMC) group …
Defining The Destruction Box: Understanding How The Apc Recognizes Its Substrates, Hana Maldivita Tambrin, Mark C. Hall
Defining The Destruction Box: Understanding How The Apc Recognizes Its Substrates, Hana Maldivita Tambrin, Mark C. Hall
The Summer Undergraduate Research Fellowship (SURF) Symposium
Cell division is the process by which mother cells give rise to two genetically identical daughter cells. All cells have protein networks to ensure that cell division is completed correctly because mistakes during cell division may cause diseases. The Anaphase-promoting complex (APC) is an important regulatory enzyme that ensures successful completion of mitosis. It acts by removing inhibitors of chromosomal segregation and cytokinesis, as well as other important cell division regulators. Existing chemotherapies, like taxol, act by indirectly inhibiting APC function. This makes APC a potential target for new cancer chemotherapies. However, designing APC inhibitors is challenging because how APC …