Biochemistry, Biophysics, and Structural Biology Commons^™

Fatty Acid Biomarkers Of Dairy Fat Consumption And Incidence Of Type 2 Diabetes: A Pooled Analysis Of Prospective Cohort Studies, Fumiaki Imamura, Amanda Fretts, Matti Marklund, Andres V. Ardisson Korat, Wei-Sin Yang, Maria Lankinen, Waqas Qureshi, Catherine Helmer, Tzu-An Chen, Kerry Wong, Julie K. Bassett, Rachel Murphy, Nathan L. Tintle, Chaoyu Ian Yu, Ingeborg A. Brouwer, Kuo-Liong Chien, Alexis C. Frazier-Wood, Liana C. Del Gobbo, Luc Djousse, Johanna M. Geleijnse, Graham G. Giles, Janette De Goede, Vilmunder Gudnason, William S. Harris, Allison Hodge, Frank Hu, Interact Consortium, Albert Koulman, Markku Laakso, Lars Lind, Hung-Ju Lin, Barbara Mcknight, Kalina Rajaobelina, Ulf Riserus, Jennifer G. Robinson, Cecilia Samieri, David S. Siscovick, Sabita S. Soedamah-Muthu, Nona Sotoodehnia, Qi Sun, Michael Y. Tsai, Matti Uusitupa, Lynne E. Wageknecht, Nick J. Wareham, Jason Hy Wu, Renata Micha, Nita G. Forouhi, Rozenn N. Lemaitre, Dariush Mozaffarian, Fatty Acids And Outcomes Research Consortium

Faculty Work Comprehensive List

Background

We aimed to investigate prospective associations of circulating or adipose tissue odd-chain fatty acids 15:0 and 17:0 and trans-palmitoleic acid, t16:1n-7, as potential biomarkers of dairy fat intake, with incident type 2 diabetes (T2D).

Methods and findings

Sixteen prospective cohorts from 12 countries (7 from the United States, 7 from Europe, 1 from Australia, 1 from Taiwan) performed new harmonised individual-level analysis for the prospective associations according to a standardised plan. In total, 63,682 participants with a broad range of baseline ages and BMIs and 15,180 incident cases of T2D over the average of 9 years of follow-up were …