Biochemistry, Biophysics, and Structural Biology Commons^™

Homologous Recombination In Protozoan Parasites And Recombinase Inhibitors, Andrew A. Kelso, Sarah M. Waldvogel, Adam J. Luthman, Michael G. Sehorn

Publications

Homologous recombination (HR) is a DNA double-strand break (DSB) repair pathway that utilizes a homologous template to fully repair the damaged DNA. HR is critical to maintain genome stability and to ensure genetic diversity during meiosis. A specialized class of enzymes known as recombinases facilitate the exchange of genetic information between sister chromatids or homologous chromosomes with the help of numerous protein accessory factors. The majority of the HR machinery is highly conserved among eukaryotes. In many protozoan parasites, HR is an essential DSB repair pathway that allows these organisms to adapt to environmental conditions and evade host immune systems …