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Full-Text Articles in Biochemistry, Biophysics, and Structural Biology
Characterization Of Tau Disease-Associated Mutation, R5l, On Microtubule Bound Tau Behavoir And Function, Alisa Cario
Characterization Of Tau Disease-Associated Mutation, R5l, On Microtubule Bound Tau Behavoir And Function, Alisa Cario
Graduate College Dissertations and Theses
Proper coordination of the neuronal cytoskeleton is necessary for the health of the nervous system. Regulation of the microtubule cytoskeleton is achieved, in part, through microtubule associated proteins (MAPs). MAP-Tau, an intrinsically disordered protein highly expressed in axons, functions in signaling cascades, regulation of motor motility, as well as the direct regulation of microtubule dynamics. Tau misregulation and mutations are linked to a class of neurodegenerative diseases called Tauopathies, characterized by the aggregation of Tau. These include progressive supranuclear palsy (PSP), Pick's disease, and Alzheimer's disease. Many of the disease-associated mutations in Tau are found in the microtubule-binding domain, in …
Novel Pausing Behavior Of The Kinesin-3 Family Member Kif1a Is Regulated By Tau, Dominique V. Lessard
Novel Pausing Behavior Of The Kinesin-3 Family Member Kif1a Is Regulated By Tau, Dominique V. Lessard
Graduate College Dissertations and Theses
The unique relationship between neuronal structure and function is paramount for the complexity of the human nervous system. This relationship allows neurons to receive, process, and transmit information through many inter- and intracellular mechanisms. Axonal transport is an essential intracellular mechanism for neuronal health and viability. This process involves the transport of cellular cargo in the anterograde and retrograde direction along the axon, relaying materials between the soma and axon terminals, respectively. The necessity of an expedited form of transport becomes clear when one considers the magnitude of distance cargo must travel; in some cases, the axon can be up …
Single Molecule Imaging Reveals Tau Structure And Function On The Microtubule Surface, Jamie Stern
Single Molecule Imaging Reveals Tau Structure And Function On The Microtubule Surface, Jamie Stern
Graduate College Dissertations and Theses
Neurons are among the most highly polarized cells in the human body. This polarization allows the neuron to participate in the transfer of chemical and electrical signals which are crucial to the survival of the organism. As part of polarization, each neuron develops a dendritic arbor and an axon. To ensure the survival of the cell, materials synthesized in the cell body must be trafficked through the axon for delivery throughout ultimately ending at the synaptic termini. The bulk of this cargo transport is microtubule-based fast axonal transport which is molecular motor mediated and tightly regulated though many pathways. Motor …