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Full-Text Articles in Biochemistry, Biophysics, and Structural Biology
Mechanism Of Cadmium-Mediated Inhibition Of Msh2-Msh6 Function In Dna Mismatch Repair, Manju Hingorani
Mechanism Of Cadmium-Mediated Inhibition Of Msh2-Msh6 Function In Dna Mismatch Repair, Manju Hingorani
Manju Hingorani
The observation that Cadmium (Cd(2+)) inhibits Msh2-Msh6, which is responsible for identifying base pair mismatches and other discrepancies in DNA, has led to the proposal that selective targeting of this protein and consequent suppression of DNA repair or apoptosis promote the carcinogenic effects of the heavy metal toxin. It has been suggested that Cd(2+) binding to specific sites on Msh2-Msh6 blocks its DNA binding and ATPase activities. To investigate the mechanism of inhibition, we measured Cd(2+) binding to Msh2-Msh6, directly and by monitoring changes in protein structure and enzymatic activity. Global fitting of the data to a multiligand binding model …
The Conformational Dynamics Of The M3-M4 Loop Of The Na+/K+-Atpase Are Influenced By Cation Concentration, Robert Dempski, S Geys, E Bamberg
The Conformational Dynamics Of The M3-M4 Loop Of The Na+/K+-Atpase Are Influenced By Cation Concentration, Robert Dempski, S Geys, E Bamberg
Robert E. Dempski
No abstract provided.
Structure Of Momoneric Yeast And Mammalian Sec61 Complexes Interacting With The Translating Ribosome, Elisabet Mandon
Structure Of Momoneric Yeast And Mammalian Sec61 Complexes Interacting With The Translating Ribosome, Elisabet Mandon
Elisabet Mandon
No abstract provided.