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Full-Text Articles in Biochemistry, Biophysics, and Structural Biology
Improving Probabilistic Infectious Disease Forecasting Through Coherence, Graham Casey Gibson, Kelly R. Moran, Nicholas G. Reich, Dave Osthus
Improving Probabilistic Infectious Disease Forecasting Through Coherence, Graham Casey Gibson, Kelly R. Moran, Nicholas G. Reich, Dave Osthus
Biostatistics and Epidemiology Faculty Publications Series
Author summary Seasonal influenza causes a significant public health burden nationwide. Accurate influenza forecasting may help public health officials allocate resources and plan responses to emerging outbreaks. The U.S. Centers for Disease Control and Prevention (CDC) reports influenza data at multiple geographical units, including regionally and nationally, where the national data are by construction a weighted sum of the regional data. In an effort to improve influenza forecast accuracy across all models submitted to the CDC's annual flu forecasting challenge, we examined the effect of imposing this geographical constraint on the set of independent forecasts, made publicly available by the …
Unraveling The Mechanisms Of Surround Suppression In Early Visual Processing, Yao Li, Lai-Sang Young
Unraveling The Mechanisms Of Surround Suppression In Early Visual Processing, Yao Li, Lai-Sang Young
Mathematics and Statistics Department Faculty Publication Series
This paper uses mathematical modeling to study the mechanisms of surround suppression in the primate visual cortex. We present a large-scale neural circuit alistic modeling work are used. The remaining parameters are chosen to produce model outputs that emulate experimentally observed size-tuning curves. Our two main results are: (i) we discovered the character of the long-range connections in Layer 6 responsible for surround effects in the input layers; and (ii) we showed that a net-inhibitory feedback, i.e., feedback that excites I-cells more than E-cells, from Layer 6 to Layer 4 is conducive to producing surround properties consistent with experimental data. …