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Full-Text Articles in Biochemistry, Biophysics, and Structural Biology
Targeting The Phgdh-Mtor Metabolic Axis In Osteosarcoma, Richa Rathore
Targeting The Phgdh-Mtor Metabolic Axis In Osteosarcoma, Richa Rathore
Arts & Sciences Electronic Theses and Dissertations
Altering cellular energy metabolism has been highlighted as one of the emerging hallmarks of cancer. The reprogramming of bioenergetic pathways towards enhanced glycolysis, rather than the mitochondrial oxidative phosphorylation indicative of normal cells, results in increased biomass production and is associated with the activation of various oncogenes. The increased or decreased expression of key metabolic enzymes has been identified as a potential family of biomarkers that could serve as the targets for novel metabolic-based therapies in cancer.
The serine, glycine, and one-carbon (SGOC) metabolism pathway consists of a series of enzymes and metabolites that drive protein and lipid production, enhanced …