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Placental Microrna Expression In Pregnancies Complicated With Preeclampsia And Intrauterine Growth Restriction, Zain Awamleh

Electronic Thesis and Dissertation Repository

A normally developed placenta is integral to a successful pregnancy. Preeclampsia (PE) and intrauterine growth restriction (IUGR) are two common pregnancy related complications that result from abnormal placental development. Placental microRNAs (miRNAs) have been investigated as potential biomarkers for these complications, but they may also play a role in placental development and pathophysiology by influencing gene expression. The objectives of this study are (i) to utilize next-generation sequencing to determine miRNA and gene expression in human placental (chorionic villous) samples from three distinct patient groups with early-onset (EO) PE, IUGR, or PE + IUGR, and (ii) integration of expression datasets …