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Full-Text Articles in Biochemistry, Biophysics, and Structural Biology
The Role Of Cd53 In Hematopoietic Development, Stress, And Malignancy, Zev Joshua Greenberg
The Role Of Cd53 In Hematopoietic Development, Stress, And Malignancy, Zev Joshua Greenberg
Arts & Sciences Electronic Theses and Dissertations
For a cell to function properly, it must be able to interact with and respond to environmental cues; however, expression of surface molecules, proteins, and receptors is not always sufficient to execute a cellular response. Proper organization of the plasma membrane is necessary to facilitate these highly regulated protein interactions, such that a cell can respond to stressors, growth factors, and other signaling molecules. Tetraspanins are a family of transmembrane proteins which help correctly orient surface molecules on the cell membrane, often through tetraspanin enriched microdomains, a membrane structure similar to lipid rafts. As a family, tetraspanins are known to …
The Role Of Mature Secretory Cells In Gastrointestinal Regeneration, Megan Deanna Radyk
The Role Of Mature Secretory Cells In Gastrointestinal Regeneration, Megan Deanna Radyk
Arts & Sciences Electronic Theses and Dissertations
Differentiated cells exhibit the ability to adjust their cell fate and become more progenitor-like after wide-scale tissue injury. This inherent cell plasticity is shown across many tissues and organisms and is a conserved behavior that ensures organ function even in a chronic injury setting. At the tissue level, the change in cell fate from a differentiated cell to one with more progenitor properties can be identified as metaplasia. Importantly, metaplasias, like Spasmolytic Polypeptide-Expressing Metaplasia (SPEM) in the stomach and Acinar-to-Ductal Metaplasia (ADM) in the pancreas, are risk factors for the development of adenocarcinoma. Thus, understanding the cellular and molecular mechanisms …