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Full-Text Articles in Biochemistry, Biophysics, and Structural Biology
Neurotrophins And Their Effects On Breast Cancer Cell Proliferation And Migration, Kayla Elise Minser
Neurotrophins And Their Effects On Breast Cancer Cell Proliferation And Migration, Kayla Elise Minser
Open Access Theses
Cancer is a large health issue in all parts of the world. In the United States alone, approximately 1 in 4 deaths are cancer related. Breast cancer is a particularly prevalent form, accounting for a little over 14 percent of all cancer incidence. The largest obstacle to overcome for breast cancer morbidity is metastasis. Over 90 percent of all breast cancer related deaths are due to metastasis. Because metastasis is a complex, multi-step process, it is difficult to treat. A recent observation in the Kirshner lab has revealed a type of phenotypic plasticity, where migratory cancer cells have a neuronal-like …
Interaction Between Centromeric Histone H3 Variant And Shugoshin, Visarut Buranasudja
Interaction Between Centromeric Histone H3 Variant And Shugoshin, Visarut Buranasudja
Open Access Theses
Precise and faithful segregation of chromosome segregation during mitosis depends on the ability of the cell to regulate chromosome bi-orientation on the mitotic spindle. Shugoshin (Sgo1), the protector of meiotic centromeric cohesin, is required for proper establishment of chromosome bi-orientation. Sgo1 plays a crucial role as part of a mitotic tension sensor between sister chromatids. Recently, Sgo1 has been reported to interact with histone H3 at the pericentromere region, as an important factor for tension sensing and chromosome segregation. However, the role of Sgo1 in tension sensing at centromere is still elusive. The centromere is the region of attachment of …