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Full-Text Articles in Biochemistry, Biophysics, and Structural Biology
Investigating Factors That Affect Hiv-1 Capsid Stability, Max Mao, Joshua Temple
Investigating Factors That Affect Hiv-1 Capsid Stability, Max Mao, Joshua Temple
The Yale Undergraduate Research Journal
TKH HIV caSVLd, a SURWHLQ VKHOO cRPSRVHd RI PRQRPHULc XQLWV RI CA, IRUPV a IXOOHUHQH cRQH WKaW SURWHcWV HIV¶V YLUaO JHQRPH aQd enzymes during infection. I am interested in elucidating the factors that influence stability of the capsid shell and capturing the structural interactions between HIV capsid, host restriction factors, and small molecules using biochemical and structural biology techniques. HIV capsid shell was broken down and purified into hexamer and pentamer units for in vitro study. Structural assays were performed using X-ray crystallography and biochemical analysis was performed using pelleting assays. By understanding capsid structure with factors that confer stability, …
Altering Sensory Learning By Chronic Inactivation Of Vip Interneurons, Christopher Alba, Hannah Selwyn, Katie Ferguson, Jessica Cardin
Altering Sensory Learning By Chronic Inactivation Of Vip Interneurons, Christopher Alba, Hannah Selwyn, Katie Ferguson, Jessica Cardin
The Yale Undergraduate Research Journal
Vasoactive intestinal polypeptide-expressing interneurons (VIP-INs) play a key role in the regulation of cortical circuits and are implicated in perceptual function and psychiatric disease. However, their role in perceptual augmentation and learning remains understudied. We performed chronic, localized ablation of VIP-INs in the primary visual cortex of adult mice using caspase-induced apoptosis to better understand how VIP-INs contribute to visual perception and the ability to learn a visual detection task. We find that chronic VIP-IN ablation does not affect naïve performance on a full-screen visual contrast detection task. However, mice with suppressed levels of VIP-INs achieved their final expert state …