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Cell and Developmental Biology
Wayne State University Dissertations
Adherent junction, apoptosis, metastasis, PH domain, pyrimidine biosynthesis, S phase progression
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The Role Of Cad,Flash And Fam129b In Cancer Cell Survial And Apoptosis, Song Chen
The Role Of Cad,Flash And Fam129b In Cancer Cell Survial And Apoptosis, Song Chen
Wayne State University Dissertations
Apoptosis is a normal process in the human body. However, apoptosis is desregulated in cancer cells. Most cancer cells gain resistance to apoptosis, leading to uncontrolled proliferation. In this dissertation, we identified three proteins, associated with apoptosis pathway. 1) CAD, a large multifunctional complex that is invariably elevated in tumor cells, 2) FLASH, a large protein with multiple growth related functions and 3) FAM129B. We demonstrate that CAD could interact with FLASH by using yeast two hybrid, co-immunopreciptation and fluorescence microscopy. In addition, functional analysis using siRNA technology further indicated that CAD could co-operate with FLASH and play roles in …