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Full-Text Articles in Biochemistry, Biophysics, and Structural Biology
Mechanistic And Translational Studies On Skeletal Malignancies, Jeremy Mcguire
Mechanistic And Translational Studies On Skeletal Malignancies, Jeremy Mcguire
USF Tampa Graduate Theses and Dissertations
New treatment strategies are desperately needed for treating skeletal malignancy. Skeletal malignancies can be either primary cancer that originated in the bone, such as osteosarcoma, or metastatic cancer that spread from another organ to the skeleton, as in the case of breast or prostate cancer. In this thesis, I will detail two projects that focus on the discovery of new treatment strategies for both primary skeletal malignancy and metastatic skeletal malignancy.
The first project focuses on the primary skeletal malignancy, osteosarcoma, a rare cancer that is commonly diagnosed in children and young adults and metastasizes to the lungs. The survival …
Mechanisms And Molecular Biology Of Major Tumor Suppressors, Brienne E. Engel
Mechanisms And Molecular Biology Of Major Tumor Suppressors, Brienne E. Engel
USF Tampa Graduate Theses and Dissertations
This dissertation is devoted to the study of the molecular biology of major tumor suppressors, defined as those that prevent the cellular processes identified as the hallmarks of cancer. Specifically, the major tumor suppressors pRb and STK11 are explored in the context of osteosarcoma and lung cancer, respectively.
RB1 was the first tumor suppressor gene discovered. Over four decades of work have revealed that the Rb protein (pRb) is a master regulator of biological pathways influencing virtually every aspect of intrinsic cell fate including cell growth, cell-cycle checkpoints, differentiation, senescence, self-renewal, replication, genomic stability and apoptosis. While these many processes …