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Full-Text Articles in Biochemistry, Biophysics, and Structural Biology
Pgf2Α-Associated Vascular Smooth Muscle Hypertrophy Is Ros Dependent And Involves The Activation Of Mtor, P70s6k, And Pten, Kevin Rice, Sreevani Uddemarri, Devashish Desai, Ryan Morrison, R. Harris, Eric Blough
Pgf2Α-Associated Vascular Smooth Muscle Hypertrophy Is Ros Dependent And Involves The Activation Of Mtor, P70s6k, And Pten, Kevin Rice, Sreevani Uddemarri, Devashish Desai, Ryan Morrison, R. Harris, Eric Blough
Eric Blough
Prostaglandin F2α (PGF2α) increases reactive oxygen species (ROS) and induces vascular smooth muscle cell (VSMC) hypertrophy by largely unknown mechanism(s). To investigate the signaling events governing PGF2α –induced VSMC hypertrophy we examined the ability of the PGF2α analog, fluprostenol to elicit phosphorylation of Akt, the mammalian target of rapamycin (mTOR), ribosomal protein S6 kinase (p70S6k), glycogen synthase kinase-3β (GSK-3β), phosphatase and tensin homolog (PTEN), extracellular signal-regulated kinase 1/2 (ERK1/2) and Jun N-terminal kinase (JNK) in growth arrested A7r5 VSMC. Fluprostenol-induced hypertrophy was associated with increased ROS, mTOR translocation from the nucleus to the cytoplasm, along with Akt, mTOR, GSK-3β, PTEN …