Open Access. Powered by Scholars. Published by Universities.®
Biochemistry, Biophysics, and Structural Biology Commons™
Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Biochemistry, Biophysics, and Structural Biology
Superoxide Dismutase C Modulates Macropinocytosis And Phagocytosis In Dictyostelium Discoideum, Cong Gu
Superoxide Dismutase C Modulates Macropinocytosis And Phagocytosis In Dictyostelium Discoideum, Cong Gu
FIU Electronic Theses and Dissertations
Macropinocytosis and phagocytosis, two actin-dependent and clathrin independent events of endocytosis, enable the cells such as macrophages and neutrophils to either internalize pathogens and initiates the human innate immune response or serve as a direct entry route for productive infection of pathogen. Dictyostelium discoideum, soil-living amoeba, a unicellular eukaryote that could professionally internalize fluid phase or particles several folds more than that of macrophages and neutrophils. Additionally, multiple key signaling pathways are conserved between Dictyostelium and mammalian cells, including pathways affecting small GTPases Ras and Rac and their downstream effectors, and F-Actin remodeling. All these traits makes Dictyostelium an …
Regulation Of Particle Uptake By Pp2a/B56 And Lkb1 In Dictyostelium Discoideum, Mujataba Rahiman Sharief
Regulation Of Particle Uptake By Pp2a/B56 And Lkb1 In Dictyostelium Discoideum, Mujataba Rahiman Sharief
FIU Electronic Theses and Dissertations
Dictyostelium discoideum is a soil dwelling amoeba which has been widely used as a model organism to study cellular processes such as signal transduction, chemotaxis, endocytosis and exocytosis. The process of phagocytosis in Dicytostelium is largely comparable to that of neutrophils and macrophages in the mammalian system. Neutrophils and macrophages are cells of the innate immune system and they engulf infectious bacteria through phagocytosis. Dictyostelium cells uptake yeast and bacteria for their nutrition through phagocytosis, which is an actin dependent mechanism and is a target of multiple signaling inputs. Recent studies have uncovered different proteins involved in the signaling of …